Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice

Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1) not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum monitoring...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0119547-e0119547
Hauptverfasser:	Szalai, Gabor, Romero, Roberto, Chaiworapongsa, Tinnakorn, Xu, Yi, Wang, Bing, Ahn, Hyunyoung, Xu, Zhonghui, Chiang, Po Jen, Sundell, Birgitta, Wang, Rona, Jiang, Yang, Plazyo, Olesya, Olive, Mary, Tarca, Adi L, Dong, Zhong, Qureshi, Faisal, Papp, Zoltan, Hassan, Sonia S, Hernandez-Andrade, Edgar, Than, Nandor Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Age Albumin Amino Acid Sequence Angiogenesis Animal models Animals Aorta Blood Blood Pressure Blood Pressure Monitors Carotid artery Catheters Cell adhesion & migration Cesarean section Childrens health Creatinine Disease Models, Animal Female Fetuses Fluorescence Gene Expression Profiling Gestational Age Green fluorescent protein Green Fluorescent Proteins - genetics Gynecology Humans Hypertension Liver Liver diseases Medical research Medicine Mice Mice, Transgenic Molecular Sequence Data Monitoring Obstetrics Pathology Phenotype Placenta Placenta - diagnostic imaging Placenta - pathology Placenta - physiopathology Postpartum Pre-eclampsia Pre-Eclampsia - etiology Pre-Eclampsia - pathology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Pressure measurement Pressure measurements Protein Isoforms - administration & dosage Protein Isoforms - genetics Protein Isoforms - physiology Protein-tyrosine kinase Recombinant Proteins - administration & dosage Recombinant Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sequence Homology, Amino Acid Species Specificity Surgery Surgical implants Survival Telemetry Tyrosine Ultrasonography Ultrasound Urine Vascular Endothelial Growth Factor Receptor-1 - administration & dosage Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - physiology
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