Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer
POTEE (POTE ankyrin domain family, member E) is a newly identified cancer-testis antigen that has been found to be expressed in a wide variety of human cancers including cancers of the colon, prostate, lung, breast, ovary, and pancreas. To measure the serum levels of POTEE in patients with non-small...
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0122792-e0122792 |
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| creator | Wang, Qi Li, Xuefei Ren, Shengxiang Cheng, Ningning Zhao, Mingchuan Zhang, Yishi Li, Jiayu Cai, Weijing Zhao, Chao Cao, Wa Zhou, Caicun |
| description | POTEE (POTE ankyrin domain family, member E) is a newly identified cancer-testis antigen that has been found to be expressed in a wide variety of human cancers including cancers of the colon, prostate, lung, breast, ovary, and pancreas.
To measure the serum levels of POTEE in patients with non-small-cell lung cancer (NSCLC) and to explore the clinical significance of POTEE in NSCLC.
104 NSCLC patients, 66 benign lung disease patients and 80 healthy volunteers were enrolled in this study from May 2013 to February 2014. Serum POTEE levels were measured using enzyme-linked immunosorbent assay (ELISA). Numerical variables were recorded as means ± standard deviation (SD) and analyzed by independent t tests. Categorical variables were calculated as rates and were analyzed using a χ2 test or Fisher's exact test. Survival curves were estimated and compared using the Kaplan-Meier method and log-rank tests.
Serum POTEE levels were significantly higher in NSCLC patients than in benign lung disease patients and healthy controls (mean ± SD [pg/ml], 324.38± 13.84 vs. 156.93 ± 17.38 and 139.09 ± 15.80, P |
| doi_str_mv | 10.1371/journal.pone.0122792 |
| format | Article |
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To measure the serum levels of POTEE in patients with non-small-cell lung cancer (NSCLC) and to explore the clinical significance of POTEE in NSCLC.
104 NSCLC patients, 66 benign lung disease patients and 80 healthy volunteers were enrolled in this study from May 2013 to February 2014. Serum POTEE levels were measured using enzyme-linked immunosorbent assay (ELISA). Numerical variables were recorded as means ± standard deviation (SD) and analyzed by independent t tests. Categorical variables were calculated as rates and were analyzed using a χ2 test or Fisher's exact test. Survival curves were estimated and compared using the Kaplan-Meier method and log-rank tests.
Serum POTEE levels were significantly higher in NSCLC patients than in benign lung disease patients and healthy controls (mean ± SD [pg/ml], 324.38± 13.84 vs. 156.93 ± 17.38 and 139.09 ± 15.80, P<0.001) and were significantly correlated with TNM stage. Survival analysis revealed that patients with low serum POTEE had longer progression-free survival (PFS) than those with high serum POTEE (P=0.021). Cox multivariate analysis indicated that POTEE was an independent prognostic factor of progression-free survival (P =0.009, hazard ratio, 2.440).
Serum POTEE level in NSCLC patients is associated with TNM stage and is a potential prognostic factor.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0122792</identifier><identifier>PMID: 25860145</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Ankyrins ; Antigens ; Antigens, Neoplasm - blood ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Apoptosis ; Benign ; Biomarkers ; Biomarkers, Tumor ; Cancer ; Carcinoma, Non-Small-Cell Lung - blood ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - mortality ; Case-Control Studies ; Clinical significance ; Colon ; Correlation analysis ; Development and progression ; Disease control ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Genes ; Genetic aspects ; Genomes ; Hospitals ; Humans ; Immunology ; Immunotherapy ; Independent variables ; Kaplan-Meier Estimate ; Lung cancer ; Lung diseases ; Lung Neoplasms - blood ; Lung Neoplasms - diagnosis ; Lung Neoplasms - mortality ; Male ; Medical diagnosis ; Medical prognosis ; Medical research ; Medical schools ; Melanoma ; Middle Aged ; Multivariate analysis ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Pancreas ; Patients ; Peptides ; Physiological aspects ; Prostate ; Proteins ; Rank tests ; Risk Factors ; ROC Curve ; Serum levels ; Software ; Stem cells ; Survival ; Treatment Outcome ; Tumor antigens</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0122792-e0122792</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Wang et al 2015 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2ad1c21359cf29b364cf421c01ddbd468dcfcec7599b51e9b340429513e359713</citedby><cites>FETCH-LOGICAL-c692t-2ad1c21359cf29b364cf421c01ddbd468dcfcec7599b51e9b340429513e359713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393100/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393100/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25860145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Coleman, William B.</contributor><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Ren, Shengxiang</creatorcontrib><creatorcontrib>Cheng, Ningning</creatorcontrib><creatorcontrib>Zhao, Mingchuan</creatorcontrib><creatorcontrib>Zhang, Yishi</creatorcontrib><creatorcontrib>Li, Jiayu</creatorcontrib><creatorcontrib>Cai, Weijing</creatorcontrib><creatorcontrib>Zhao, Chao</creatorcontrib><creatorcontrib>Cao, Wa</creatorcontrib><creatorcontrib>Zhou, Caicun</creatorcontrib><title>Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>POTEE (POTE ankyrin domain family, member E) is a newly identified cancer-testis antigen that has been found to be expressed in a wide variety of human cancers including cancers of the colon, prostate, lung, breast, ovary, and pancreas.
To measure the serum levels of POTEE in patients with non-small-cell lung cancer (NSCLC) and to explore the clinical significance of POTEE in NSCLC.
104 NSCLC patients, 66 benign lung disease patients and 80 healthy volunteers were enrolled in this study from May 2013 to February 2014. Serum POTEE levels were measured using enzyme-linked immunosorbent assay (ELISA). Numerical variables were recorded as means ± standard deviation (SD) and analyzed by independent t tests. Categorical variables were calculated as rates and were analyzed using a χ2 test or Fisher's exact test. Survival curves were estimated and compared using the Kaplan-Meier method and log-rank tests.
Serum POTEE levels were significantly higher in NSCLC patients than in benign lung disease patients and healthy controls (mean ± SD [pg/ml], 324.38± 13.84 vs. 156.93 ± 17.38 and 139.09 ± 15.80, P<0.001) and were significantly correlated with TNM stage. Survival analysis revealed that patients with low serum POTEE had longer progression-free survival (PFS) than those with high serum POTEE (P=0.021). Cox multivariate analysis indicated that POTEE was an independent prognostic factor of progression-free survival (P =0.009, hazard ratio, 2.440).
Serum POTEE level in NSCLC patients is associated with TNM stage and is a potential prognostic factor.</description><subject>Aged</subject><subject>Ankyrins</subject><subject>Antigens</subject><subject>Antigens, Neoplasm - blood</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Apoptosis</subject><subject>Benign</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor</subject><subject>Cancer</subject><subject>Carcinoma, Non-Small-Cell Lung - blood</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Case-Control Studies</subject><subject>Clinical significance</subject><subject>Colon</subject><subject>Correlation analysis</subject><subject>Development and progression</subject><subject>Disease control</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Independent variables</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical schools</subject><subject>Melanoma</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Pancreas</subject><subject>Patients</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Prostate</subject><subject>Proteins</subject><subject>Rank tests</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Serum levels</subject><subject>Software</subject><subject>Stem cells</subject><subject>Survival</subject><subject>Treatment Outcome</subject><subject>Tumor antigens</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAYhSMEYmPwDxBEQkJwkeKvfPgGaZoKVJo0xAa3luO8SV0cu8TOBP8et82mBu0C-cKO_Zzj-NhvkrzEaIFpiT9s3DhYaRZbZ2GBMCElJ4-SU8wpyQqC6OOj8UnyzPsNQjmtiuJpckLyqkCY5afJz2sYxj41cAvGp65NwxpSJa2CIQvgg_aptEF3YNOvVzfLZfxqUh18qoy2WkmTet1Z3eq9JtU2tc5mvpfGZAqMSc1ou8nwefKklcbDi6k_S75_Wt5cfMkurz6vLs4vM1VwEjIiG6wIpjlXLeE1LZhqGcEK4aapG1ZUjWoVqDLnvM4xRIIhRniOKURNielZ8vrguzXOiyknL3BRElIxlBeRWB2IxsmN2A66l8Mf4aQW-wk3dEIOQSsDomQVLxWqW96UrChwDQ0o4KRmLAfCSPT6OO021j00CmwYpJmZzlesXovO3QpGOcUIRYN3k8Hgfo0xc9Frv8tOWnDj_r8pKmmFWUTf_IM-fLqJ6mQ8gLati_uqnak4Z6TIqxLjMlKLB6jYGui1io-q1XF-Jng_E0QmwO_QydF7sbr-9v_s1Y85-_aIXYM0Ye2dGYN21s9BdgDV4LwfoL0PGSOxq4m7NMSuJsRUE1H26viC7kV3RUD_Auf-Bek</recordid><startdate>20150410</startdate><enddate>20150410</enddate><creator>Wang, Qi</creator><creator>Li, Xuefei</creator><creator>Ren, Shengxiang</creator><creator>Cheng, Ningning</creator><creator>Zhao, Mingchuan</creator><creator>Zhang, Yishi</creator><creator>Li, Jiayu</creator><creator>Cai, Weijing</creator><creator>Zhao, Chao</creator><creator>Cao, Wa</creator><creator>Zhou, Caicun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150410</creationdate><title>Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer</title><author>Wang, Qi ; Li, Xuefei ; Ren, Shengxiang ; Cheng, Ningning ; Zhao, Mingchuan ; Zhang, Yishi ; Li, Jiayu ; Cai, Weijing ; Zhao, Chao ; Cao, Wa ; Zhou, Caicun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2ad1c21359cf29b364cf421c01ddbd468dcfcec7599b51e9b340429513e359713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Ankyrins</topic><topic>Antigens</topic><topic>Antigens, Neoplasm - blood</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Apoptosis</topic><topic>Benign</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor</topic><topic>Cancer</topic><topic>Carcinoma, Non-Small-Cell Lung - blood</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Case-Control Studies</topic><topic>Clinical significance</topic><topic>Colon</topic><topic>Correlation analysis</topic><topic>Development and progression</topic><topic>Disease control</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Independent variables</topic><topic>Kaplan-Meier Estimate</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical schools</topic><topic>Melanoma</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Peptides</topic><topic>Physiological aspects</topic><topic>Prostate</topic><topic>Proteins</topic><topic>Rank tests</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Serum levels</topic><topic>Software</topic><topic>Stem cells</topic><topic>Survival</topic><topic>Treatment Outcome</topic><topic>Tumor antigens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Ren, Shengxiang</creatorcontrib><creatorcontrib>Cheng, Ningning</creatorcontrib><creatorcontrib>Zhao, Mingchuan</creatorcontrib><creatorcontrib>Zhang, Yishi</creatorcontrib><creatorcontrib>Li, Jiayu</creatorcontrib><creatorcontrib>Cai, Weijing</creatorcontrib><creatorcontrib>Zhao, Chao</creatorcontrib><creatorcontrib>Cao, Wa</creatorcontrib><creatorcontrib>Zhou, Caicun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qi</au><au>Li, Xuefei</au><au>Ren, Shengxiang</au><au>Cheng, Ningning</au><au>Zhao, Mingchuan</au><au>Zhang, Yishi</au><au>Li, Jiayu</au><au>Cai, Weijing</au><au>Zhao, Chao</au><au>Cao, Wa</au><au>Zhou, Caicun</au><au>Coleman, William B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-10</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0122792</spage><epage>e0122792</epage><pages>e0122792-e0122792</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>POTEE (POTE ankyrin domain family, member E) is a newly identified cancer-testis antigen that has been found to be expressed in a wide variety of human cancers including cancers of the colon, prostate, lung, breast, ovary, and pancreas.
To measure the serum levels of POTEE in patients with non-small-cell lung cancer (NSCLC) and to explore the clinical significance of POTEE in NSCLC.
104 NSCLC patients, 66 benign lung disease patients and 80 healthy volunteers were enrolled in this study from May 2013 to February 2014. Serum POTEE levels were measured using enzyme-linked immunosorbent assay (ELISA). Numerical variables were recorded as means ± standard deviation (SD) and analyzed by independent t tests. Categorical variables were calculated as rates and were analyzed using a χ2 test or Fisher's exact test. Survival curves were estimated and compared using the Kaplan-Meier method and log-rank tests.
Serum POTEE levels were significantly higher in NSCLC patients than in benign lung disease patients and healthy controls (mean ± SD [pg/ml], 324.38± 13.84 vs. 156.93 ± 17.38 and 139.09 ± 15.80, P<0.001) and were significantly correlated with TNM stage. Survival analysis revealed that patients with low serum POTEE had longer progression-free survival (PFS) than those with high serum POTEE (P=0.021). Cox multivariate analysis indicated that POTEE was an independent prognostic factor of progression-free survival (P =0.009, hazard ratio, 2.440).
Serum POTEE level in NSCLC patients is associated with TNM stage and is a potential prognostic factor.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25860145</pmid><doi>10.1371/journal.pone.0122792</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0122792-e0122792 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1672284056 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Ankyrins Antigens Antigens, Neoplasm - blood Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Benign Biomarkers Biomarkers, Tumor Cancer Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Case-Control Studies Clinical significance Colon Correlation analysis Development and progression Disease control Enzyme-linked immunosorbent assay Enzymes Female Genes Genetic aspects Genomes Hospitals Humans Immunology Immunotherapy Independent variables Kaplan-Meier Estimate Lung cancer Lung diseases Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - mortality Male Medical diagnosis Medical prognosis Medical research Medical schools Melanoma Middle Aged Multivariate analysis Non-small cell lung cancer Non-small cell lung carcinoma Pancreas Patients Peptides Physiological aspects Prostate Proteins Rank tests Risk Factors ROC Curve Serum levels Software Stem cells Survival Treatment Outcome Tumor antigens |
| title | Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T15%3A41%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20levels%20of%20the%20cancer-testis%20antigen%20POTEE%20and%20its%20clinical%20significance%20in%20non-small-cell%20lung%20cancer&rft.jtitle=PloS%20one&rft.au=Wang,%20Qi&rft.date=2015-04-10&rft.volume=10&rft.issue=4&rft.spage=e0122792&rft.epage=e0122792&rft.pages=e0122792-e0122792&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0122792&rft_dat=%3Cgale_plos_%3EA426587117%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672284056&rft_id=info:pmid/25860145&rft_galeid=A426587117&rft_doaj_id=oai_doaj_org_article_74897c0bf9d74661bedece92b445e242&rfr_iscdi=true |