Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer
The receptor for advanced glycation endproducts (RAGE) is an oncogenic multidisciplinary trans-membranous receptor, which is overexpressed in multiple human cancers. Recently, it has been shown that RAGE is also involved in carcinogenesis and tumor invasion. In this study, we investigated the expres...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0122697 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | e0122697 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Wang, Da Li, Tingting Ye, Gengtai Shen, Zhiyong Hu, Yanfeng Mou, Tingyu Yu, Jiang Li, Sihao Liu, Hao Li, Guoxin |
| description | The receptor for advanced glycation endproducts (RAGE) is an oncogenic multidisciplinary trans-membranous receptor, which is overexpressed in multiple human cancers. Recently, it has been shown that RAGE is also involved in carcinogenesis and tumor invasion. In this study, we investigated the expression levels and prognostic value of RAGE in primary gastric cancers (GC).
We investigated RAGE expression in primary GC and paired normal gastric tissue by real-time quantitative RT-PCR (n = 30) and Western blotting analysis (n = 30). Additionally, we performed immunohistochemistry on 180 paraffin-embedded GC specimens, 69 matched normal specimens.
RAGE was overexpressed in GC compared with the adjacent noncancerous tissues (P＜0.001), and higher RAGE expression significantly correlated with the histological grade (P = 0.002), nodal status(P = 0.025), metastasis status(P = 0.002), and American Joint Committee on Cancer stage (P = 0.020). Furthermore, upregulation of RAGE expression is an independent prognostic factor in multivariate analysis using the Cox regression model (P = 0.001).
RAGE Overexpression may be a useful marker to predict GC progression and poor prognosis. |
| doi_str_mv | 10.1371/journal.pone.0122697 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1672284008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A426587114</galeid><doaj_id>oai_doaj_org_article_a8b484696f244d2eb9e7965d861553be</doaj_id><sourcerecordid>A426587114</sourcerecordid><originalsourceid>FETCH-LOGICAL-c743t-8dd6564ae25b36d085f757cba99852e3f0a36e3991c40e6d0cbc45f0ee85199e3</originalsourceid><addsrcrecordid>eNqNkl1r2zAUhs3YWLtu_2BshsFYL5LJ1oflm0EoWRYoFLKPWyHLx46CY7mSnLWwHz95cUsMGwwhJKTnfXU4eqPodYLmCc6SjzvT21Y28860MEdJmrI8exKdJzlOZyxF-OnJ_ix64dwOIYo5Y8-js5RyhnLKzqNfNwewcNdZcE6bNjZV7LcQb0BB542NqzAX5UG2Csp41dwr6Qds2ZadNWWvvIs_bBar5WWsXSydM0pLH9Cf2m_jzgR14OrWuHCt27iWzlutYjUY2pfRs0o2Dl6N60X0_fPy29WX2fXNan21uJ6pjGA_42XJKCMSUlpgViJOq4xmqpB5zmkKuEISM8B5niiCIACqUIRWCIDTJM8BX0Rvj75dY5wYG-dEwrI05QQhHoj1kSiN3InO6r2098JILf4cGFsLab1WDQjJC8IJy1mVElKmUOSQ5YyWnCWU4mJ47dP4Wl_soVTQeiubien0ptVbUZuDIDj8VzYU8240sOa2B-f_UfJI1TJUpdvKBDO1106JBUkZ5VmSkEDN_0KFUcJeqxCdSofzieByIgiMhztfy945sf66-X_25seUfX_CbkE2futM0w9xclOQHEFljXMWqsfOJUgMyX_ohhiSL8bkB9mb064_ih6ijn8DrVD_Dw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1672284008</pqid></control><display><type>article</type><title>Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Wang, Da ; Li, Tingting ; Ye, Gengtai ; Shen, Zhiyong ; Hu, Yanfeng ; Mou, Tingyu ; Yu, Jiang ; Li, Sihao ; Liu, Hao ; Li, Guoxin</creator><creatorcontrib>Wang, Da ; Li, Tingting ; Ye, Gengtai ; Shen, Zhiyong ; Hu, Yanfeng ; Mou, Tingyu ; Yu, Jiang ; Li, Sihao ; Liu, Hao ; Li, Guoxin</creatorcontrib><description>The receptor for advanced glycation endproducts (RAGE) is an oncogenic multidisciplinary trans-membranous receptor, which is overexpressed in multiple human cancers. Recently, it has been shown that RAGE is also involved in carcinogenesis and tumor invasion. In this study, we investigated the expression levels and prognostic value of RAGE in primary gastric cancers (GC).
We investigated RAGE expression in primary GC and paired normal gastric tissue by real-time quantitative RT-PCR (n = 30) and Western blotting analysis (n = 30). Additionally, we performed immunohistochemistry on 180 paraffin-embedded GC specimens, 69 matched normal specimens.
RAGE was overexpressed in GC compared with the adjacent noncancerous tissues (P＜0.001), and higher RAGE expression significantly correlated with the histological grade (P = 0.002), nodal status(P = 0.025), metastasis status(P = 0.002), and American Joint Committee on Cancer stage (P = 0.020). Furthermore, upregulation of RAGE expression is an independent prognostic factor in multivariate analysis using the Cox regression model (P = 0.001).
RAGE Overexpression may be a useful marker to predict GC progression and poor prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0122697</identifier><identifier>PMID: 25860956</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Advanced glycation end products ; Advanced glycosylation end products ; Aged ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinogenesis ; Carcinogens ; Cell receptors ; Female ; Gastric cancer ; Gene expression ; Genetic aspects ; Glycosylation ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Metastases ; Middle Aged ; Multivariate Analysis ; Paraffin ; Physiological aspects ; Polymerase chain reaction ; Prognosis ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction ; Receptor for Advanced Glycation End Products - genetics ; Receptor for Advanced Glycation End Products - metabolism ; Regression analysis ; Regression models ; Stomach - metabolism ; Stomach - pathology ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Tissues ; Western blotting</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0122697</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Wang et al 2015 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-8dd6564ae25b36d085f757cba99852e3f0a36e3991c40e6d0cbc45f0ee85199e3</citedby><cites>FETCH-LOGICAL-c743t-8dd6564ae25b36d085f757cba99852e3f0a36e3991c40e6d0cbc45f0ee85199e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393278/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393278/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79570,79571</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25860956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Da</creatorcontrib><creatorcontrib>Li, Tingting</creatorcontrib><creatorcontrib>Ye, Gengtai</creatorcontrib><creatorcontrib>Shen, Zhiyong</creatorcontrib><creatorcontrib>Hu, Yanfeng</creatorcontrib><creatorcontrib>Mou, Tingyu</creatorcontrib><creatorcontrib>Yu, Jiang</creatorcontrib><creatorcontrib>Li, Sihao</creatorcontrib><creatorcontrib>Liu, Hao</creatorcontrib><creatorcontrib>Li, Guoxin</creatorcontrib><title>Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The receptor for advanced glycation endproducts (RAGE) is an oncogenic multidisciplinary trans-membranous receptor, which is overexpressed in multiple human cancers. Recently, it has been shown that RAGE is also involved in carcinogenesis and tumor invasion. In this study, we investigated the expression levels and prognostic value of RAGE in primary gastric cancers (GC).
We investigated RAGE expression in primary GC and paired normal gastric tissue by real-time quantitative RT-PCR (n = 30) and Western blotting analysis (n = 30). Additionally, we performed immunohistochemistry on 180 paraffin-embedded GC specimens, 69 matched normal specimens.
RAGE was overexpressed in GC compared with the adjacent noncancerous tissues (P＜0.001), and higher RAGE expression significantly correlated with the histological grade (P = 0.002), nodal status(P = 0.025), metastasis status(P = 0.002), and American Joint Committee on Cancer stage (P = 0.020). Furthermore, upregulation of RAGE expression is an independent prognostic factor in multivariate analysis using the Cox regression model (P = 0.001).
RAGE Overexpression may be a useful marker to predict GC progression and poor prognosis.</description><subject>Adult</subject><subject>Advanced glycation end products</subject><subject>Advanced glycosylation end products</subject><subject>Aged</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell receptors</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Paraffin</subject><subject>Physiological aspects</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptor for Advanced Glycation End Products - genetics</subject><subject>Receptor for Advanced Glycation End Products - metabolism</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Stomach - metabolism</subject><subject>Stomach - pathology</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Tissues</subject><subject>Western blotting</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWLtu_2BshsFYL5LJ1oflm0EoWRYoFLKPWyHLx46CY7mSnLWwHz95cUsMGwwhJKTnfXU4eqPodYLmCc6SjzvT21Y28860MEdJmrI8exKdJzlOZyxF-OnJ_ix64dwOIYo5Y8-js5RyhnLKzqNfNwewcNdZcE6bNjZV7LcQb0BB542NqzAX5UG2Csp41dwr6Qds2ZadNWWvvIs_bBar5WWsXSydM0pLH9Cf2m_jzgR14OrWuHCt27iWzlutYjUY2pfRs0o2Dl6N60X0_fPy29WX2fXNan21uJ6pjGA_42XJKCMSUlpgViJOq4xmqpB5zmkKuEISM8B5niiCIACqUIRWCIDTJM8BX0Rvj75dY5wYG-dEwrI05QQhHoj1kSiN3InO6r2098JILf4cGFsLab1WDQjJC8IJy1mVElKmUOSQ5YyWnCWU4mJ47dP4Wl_soVTQeiubien0ptVbUZuDIDj8VzYU8240sOa2B-f_UfJI1TJUpdvKBDO1106JBUkZ5VmSkEDN_0KFUcJeqxCdSofzieByIgiMhztfy945sf66-X_25seUfX_CbkE2futM0w9xclOQHEFljXMWqsfOJUgMyX_ohhiSL8bkB9mb064_ih6ijn8DrVD_Dw</recordid><startdate>20150410</startdate><enddate>20150410</enddate><creator>Wang, Da</creator><creator>Li, Tingting</creator><creator>Ye, Gengtai</creator><creator>Shen, Zhiyong</creator><creator>Hu, Yanfeng</creator><creator>Mou, Tingyu</creator><creator>Yu, Jiang</creator><creator>Li, Sihao</creator><creator>Liu, Hao</creator><creator>Li, Guoxin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150410</creationdate><title>Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer</title><author>Wang, Da ; Li, Tingting ; Ye, Gengtai ; Shen, Zhiyong ; Hu, Yanfeng ; Mou, Tingyu ; Yu, Jiang ; Li, Sihao ; Liu, Hao ; Li, Guoxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-8dd6564ae25b36d085f757cba99852e3f0a36e3991c40e6d0cbc45f0ee85199e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Advanced glycation end products</topic><topic>Advanced glycosylation end products</topic><topic>Aged</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cell receptors</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Paraffin</topic><topic>Physiological aspects</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptor for Advanced Glycation End Products - genetics</topic><topic>Receptor for Advanced Glycation End Products - metabolism</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Stomach - metabolism</topic><topic>Stomach - pathology</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Tissues</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Da</creatorcontrib><creatorcontrib>Li, Tingting</creatorcontrib><creatorcontrib>Ye, Gengtai</creatorcontrib><creatorcontrib>Shen, Zhiyong</creatorcontrib><creatorcontrib>Hu, Yanfeng</creatorcontrib><creatorcontrib>Mou, Tingyu</creatorcontrib><creatorcontrib>Yu, Jiang</creatorcontrib><creatorcontrib>Li, Sihao</creatorcontrib><creatorcontrib>Liu, Hao</creatorcontrib><creatorcontrib>Li, Guoxin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Da</au><au>Li, Tingting</au><au>Ye, Gengtai</au><au>Shen, Zhiyong</au><au>Hu, Yanfeng</au><au>Mou, Tingyu</au><au>Yu, Jiang</au><au>Li, Sihao</au><au>Liu, Hao</au><au>Li, Guoxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-10</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0122697</spage><pages>e0122697-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The receptor for advanced glycation endproducts (RAGE) is an oncogenic multidisciplinary trans-membranous receptor, which is overexpressed in multiple human cancers. Recently, it has been shown that RAGE is also involved in carcinogenesis and tumor invasion. In this study, we investigated the expression levels and prognostic value of RAGE in primary gastric cancers (GC).
We investigated RAGE expression in primary GC and paired normal gastric tissue by real-time quantitative RT-PCR (n = 30) and Western blotting analysis (n = 30). Additionally, we performed immunohistochemistry on 180 paraffin-embedded GC specimens, 69 matched normal specimens.
RAGE was overexpressed in GC compared with the adjacent noncancerous tissues (P＜0.001), and higher RAGE expression significantly correlated with the histological grade (P = 0.002), nodal status(P = 0.025), metastasis status(P = 0.002), and American Joint Committee on Cancer stage (P = 0.020). Furthermore, upregulation of RAGE expression is an independent prognostic factor in multivariate analysis using the Cox regression model (P = 0.001).
RAGE Overexpression may be a useful marker to predict GC progression and poor prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25860956</pmid><doi>10.1371/journal.pone.0122697</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0122697 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1672284008 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Advanced glycation end products Advanced glycosylation end products Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinogenesis Carcinogens Cell receptors Female Gastric cancer Gene expression Genetic aspects Glycosylation Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical prognosis Metastases Middle Aged Multivariate Analysis Paraffin Physiological aspects Polymerase chain reaction Prognosis Proportional Hazards Models Real-Time Polymerase Chain Reaction Receptor for Advanced Glycation End Products - genetics Receptor for Advanced Glycation End Products - metabolism Regression analysis Regression models Stomach - metabolism Stomach - pathology Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - mortality Stomach Neoplasms - pathology Tissues Western blotting |
| title | Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) is associated with poor prognosis in gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T07%3A07%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Overexpression%20of%20the%20Receptor%20for%20Advanced%20Glycation%20Endproducts%20(RAGE)%20is%20associated%20with%20poor%20prognosis%20in%20gastric%20cancer&rft.jtitle=PloS%20one&rft.au=Wang,%20Da&rft.date=2015-04-10&rft.volume=10&rft.issue=4&rft.spage=e0122697&rft.pages=e0122697-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0122697&rft_dat=%3Cgale_plos_%3EA426587114%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672284008&rft_id=info:pmid/25860956&rft_galeid=A426587114&rft_doaj_id=oai_doaj_org_article_a8b484696f244d2eb9e7965d861553be&rfr_iscdi=true |