Antiviral activity and possible mechanism of action of constituents identified in Paeonia lactiflora root toward human rhinoviruses

Human rhinoviruses (HRVs) are responsible for more than half of all cases of the common cold and cost billions of USD annually in medical visits and missed school and work. An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-g...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0121629
Hauptverfasser:	Ngan, Luong Thi My, Jang, Myeong Jin, Kwon, Min Jung, Ahn, Young Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - chemistry Acetophenones - isolation & purification Acetophenones - pharmacology Agricultural biotechnology Antibiotics Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral drugs Asthma Cell Line Cell Proliferation - drug effects Chromatography Constituents Cytokines Cytokines - genetics Cytokines - metabolism Drug resistance Gene expression Health aspects HeLa Cells Human behavior Humans Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - isolation & purification Hydrolyzable Tannins - pharmacology IL-1β Infections Inoculation Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Interferon Interleukin Interleukins Paeonia - chemistry Paeonia - metabolism Paeonia lactiflora Peonies Phytochemicals Plant Extracts - chemistry Plant Roots - chemistry Plant Roots - metabolism Pneumonia Polymerase chain reaction Real-Time Polymerase Chain Reaction Receptors Receptors, LDL - genetics Receptors, LDL - metabolism Replication Rhinovirus Rhinovirus - drug effects Rhinovirus - genetics Rhinovirus - physiology Rhinoviruses Ribonucleic acid RNA RNA, Viral - analysis Signs and symptoms Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Toll-like receptors Tumor necrosis factor-TNF Virus Internalization - drug effects Virus replication Virus Replication - drug effects Viruses
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