Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice

Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the enzyme hydroxy-methyl-glutaryl-coenzyme A reducta...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0122511-e0122511
Hauptverfasser:	Pathak, Rupak, Shao, Lijian, Ghosh, Sanchita P, Zhou, Daohong, Boerma, Marjan, Weiler, Hartmut, Hauer-Jensen, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants Antioxidants (Nutrients) Blood Cells - drug effects Blood Cells - metabolism Cell Line Coenzyme A Colony-stimulating factor Cytokines - biosynthesis Emergency medical services Endothelium - metabolism Endothelium - radiation effects Exposure Gene Expression Granulocyte colony-stimulating factor Health aspects Hematopoiesis - drug effects Hematopoiesis - genetics Humans Hydroxymethylglutaryl-CoA reductase In vivo methods and tests Ionizing radiation Irradiation Lethality Leukocytes Leukocytes (granulocytic) Mice Mice, Knockout Models, Animal mRNA Mutation Radiation Radiation protection Radiation-Protective Agents - pharmacology Recovery Survival Thrombomodulin Thrombomodulin - genetics Tocotrienols - pharmacology Vitamin E Whole-Body Irradiation
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