Association between alcohol consumption and pancreatic cancer risk: a case-control study
Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk. A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was...
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| description | Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk.
A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction.
Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers.
While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained. |
| doi_str_mv | 10.1371/journal.pone.0124489 |
| format | Article |
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A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction.
Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers.
While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0124489</identifier><identifier>PMID: 25856529</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Alcohol Drinking - adverse effects ; Alcohol use ; Alcoholic beverages ; Alcohols ; Cancer ; Case-Control Studies ; Cigarette smoking ; Cognitive biases ; Control methods ; Drinking (Alcoholic beverages) ; Drinking behavior ; Health aspects ; Health risks ; Humans ; Logistic Models ; Medical diagnosis ; Odds Ratio ; Ontario - epidemiology ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - etiology ; Population studies ; Risk Factors ; Risk management ; Sex Factors ; Smoking ; Subgroups</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0124489-e0124489</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Rahman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Rahman et al 2015 Rahman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-a4985f4ea450b65943f02b6db1dbcbc46cc165a46a434b1635874c5d501bea73</citedby><cites>FETCH-LOGICAL-c758t-a4985f4ea450b65943f02b6db1dbcbc46cc165a46a434b1635874c5d501bea73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25856529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Abulseoud, Osama Ali</contributor><creatorcontrib>Rahman, Farah</creatorcontrib><creatorcontrib>Cotterchio, Michelle</creatorcontrib><creatorcontrib>Cleary, Sean P</creatorcontrib><creatorcontrib>Gallinger, Steven</creatorcontrib><title>Association between alcohol consumption and pancreatic cancer risk: a case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk.
A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction.
Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers.
While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained.</description><subject>Age</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cigarette smoking</subject><subject>Cognitive biases</subject><subject>Control methods</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking behavior</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical diagnosis</subject><subject>Odds Ratio</subject><subject>Ontario - epidemiology</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - etiology</subject><subject>Population studies</subject><subject>Risk Factors</subject><subject>Risk management</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Subgroups</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7of-A9GCsOjFjPlu64UwLH4MLCzoIt6F0_R0pmOmmU1adf-96U53mcpeSC6SJs97Ts85b5K8oGROeUbfbVzvW7DznWtxTigTIi8eJce04GymGOGPD85HyUkIG0Ikz5V6mhwxmUslWXGc_FiE4EwDXePatMTuN2KbgjVu7WxqXBv67e72Ddoq3UFrPEbWpCYe0ae-CT_fpxA_A84i3vkoC11f3TxLntRgAz4f99Pk6tPHq_Mvs4vLz8vzxcXMZDLvZiCKXNYCQUhSKlkIXhNWqqqkVWlKI5QxVEkQCgQXJVVc5pkwspKElggZP01e7cPurAt67EnQVGWMFCLLVSSWe6JysNE732zB32gHjb69cH6lwceSLGpGpUEGQErJBJEk5wR5XtCai1phNWT7MGbryy1WBmPBYCdBpy9ts9Yr90sLXtCM5jHAmzGAd9c9hk5vm2DQWmjR9fv_VpQyLiL6-h_04epGagWxgKatXcxrhqB6IVicfx6NEan5A1RcFW6bODasm3g_EbydCIbR4p9uBX0Ievnt6_-zl9-n7NkBu0aw3To42w8WC1NQ7EHjXQge6_smU6IH_991Qw_-16P_o-zl4YDuRXeG538BUsP_uA</recordid><startdate>20150409</startdate><enddate>20150409</enddate><creator>Rahman, Farah</creator><creator>Cotterchio, Michelle</creator><creator>Cleary, Sean P</creator><creator>Gallinger, Steven</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150409</creationdate><title>Association between alcohol consumption and pancreatic cancer risk: a case-control study</title><author>Rahman, Farah ; Cotterchio, Michelle ; Cleary, Sean P ; Gallinger, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a4985f4ea450b65943f02b6db1dbcbc46cc165a46a434b1635874c5d501bea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Alcohol Drinking - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Farah</au><au>Cotterchio, Michelle</au><au>Cleary, Sean P</au><au>Gallinger, Steven</au><au>Abulseoud, Osama Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between alcohol consumption and pancreatic cancer risk: a case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-09</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0124489</spage><epage>e0124489</epage><pages>e0124489-e0124489</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evidence is inconsistent regarding alcohol and pancreatic cancer risk, although heavy drinking may increase risk.
A population-based case-control study was conducted using 345 pancreas cancer cases diagnosed 2011-2012 and 1,285 frequency-matched controls from Ontario, Canada. Logistic regression was used to evaluate alcohol consumption and pancreatic cancer risk; data was also stratified by sex and smoking status to assess interaction.
Alcohol consumption was not associated with pancreatic cancer risk (age-adjusted odds ratio=0.78, 95% CI: 0.58, 1.05 for 1 - 3 drinks/week; age-adjusted odds ratio=0.86, 95% CI: 0.63, 1.17 for 4 - 20 drinks/week), however there was a non-significant increased risk for heavy drinkers consuming ≥ 21 drinks/week (age-adjusted odds ratio=1.35, 95% CI: 0.81, 2.27). Cigarette smoking modified the alcohol-cancer relationship; among current smokers, heavy alcohol consumption was associated with a significantly increased pancreatic cancer risk (age-adjusted odds ratio=4.04, 95% CI: 1.58, 10.37), whereas this significant association with heavy drinking was not observed among non-smokers (age-adjusted odds ratio=2.01, 95% CI: 0.50, 8.18). Furthermore, light - moderate alcohol intake was associated with increased pancreas cancer risk among current smokers.
While alcohol was not significantly associated with pancreatic cancer risk, smoking status modified this relationship such that among current smokers, alcohol intake was associated with a greater than two-fold increased risk of pancreatic cancer. The results should be interpreted with caution due to small sample sizes within subgroups and correction for multiple comparisons should be considered. These findings should be replicated in larger studies where more precise estimates of risk can be obtained.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25856529</pmid><doi>10.1371/journal.pone.0124489</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Alcohol Drinking - adverse effects Alcohol use Alcoholic beverages Alcohols Cancer Case-Control Studies Cigarette smoking Cognitive biases Control methods Drinking (Alcoholic beverages) Drinking behavior Health aspects Health risks Humans Logistic Models Medical diagnosis Odds Ratio Ontario - epidemiology Pancreas Pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Population studies Risk Factors Risk management Sex Factors Smoking Subgroups |
| title | Association between alcohol consumption and pancreatic cancer risk: a case-control study |
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