Five-year incidence of chronic kidney disease (stage 3-5) and associated risk factors in a Spanish cohort: the MADIABETES Study
To evaluate the incidence rate of Chronic Kidney Disease (CKD) stage 3-5 (persistent decreased kidney function under 60 mL/min per 1.73 m2) among patients with type 2 diabetes over five years, to identify the risk factors associated with CKD, and develop a risk table to predict five-year CKD stage 3...
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0122030-e0122030 |
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| creator | Salinero-Fort, Miguel A San Andrés-Rebollo, Francisco J Carmen de Burgos-Lunar Gómez-Campelo, Paloma Chico-Moraleja, Rosa M López de Andrés, Ana Jiménez-García, Rodrigo Group, MADIABETES |
| description | To evaluate the incidence rate of Chronic Kidney Disease (CKD) stage 3-5 (persistent decreased kidney function under 60 mL/min per 1.73 m2) among patients with type 2 diabetes over five years, to identify the risk factors associated with CKD, and develop a risk table to predict five-year CKD stage 3-5 risk stratification for clinical use.
The MADIABETES Study is a prospective cohort study of 3,443 outpatients with type 2 diabetes mellitus, sampled from 56 primary health care centers (131 general practitioners) in Madrid (Spain).
The cumulative incidence of CKD stage 3-5 at five-years was 10.23% (95% CI = 9.12-11.44) and the incidence density was 2.07 (95% CI = 1.83-2.33) cases per 1,000 patient-months or 2.48 (95% CI = 2.19-2.79) cases per 100 patient-years. The highest hazard ratio (HR) for developing CKD stage 3-5 was albuminuria ≥ 300 mg/g (HR = 4.57; 95% CI= 2.46-8.48). Furthermore, other variables with a high HR were age over 74 years (HR = 3.20; 95% CI = 2.13-4.81), a history of Hypertension (HR = 2.02; 95% CI = 1.42-2.89), Myocardial Infarction (HR= 1.72; 95% IC= 1.25-2.37), Dyslipidemia (HR = 1.68; 95% CI 1.30-2.17), duration of diabetes mellitus ≥ 10 years (HR = 1.46; 95% CI = 1.14-1.88) and Systolic Blood Pressure >149 mmHg (HR = 1.52; 95% CI = 1.02-2.24).
After a five-year follow-up, the cumulative incidence of CKD is concordant with rates described in Spain and other countries. Albuminuria ≥ 300 mg/g and age over 74 years were the risk factors more strongly associated with developing CKD (Stage 3-5). Blood Pressure, lipid and albuminuria control could reduce CKD incidence of CKD in patients with T2DM. |
| doi_str_mv | 10.1371/journal.pone.0122030 |
| format | Article |
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The MADIABETES Study is a prospective cohort study of 3,443 outpatients with type 2 diabetes mellitus, sampled from 56 primary health care centers (131 general practitioners) in Madrid (Spain).
The cumulative incidence of CKD stage 3-5 at five-years was 10.23% (95% CI = 9.12-11.44) and the incidence density was 2.07 (95% CI = 1.83-2.33) cases per 1,000 patient-months or 2.48 (95% CI = 2.19-2.79) cases per 100 patient-years. The highest hazard ratio (HR) for developing CKD stage 3-5 was albuminuria ≥ 300 mg/g (HR = 4.57; 95% CI= 2.46-8.48). Furthermore, other variables with a high HR were age over 74 years (HR = 3.20; 95% CI = 2.13-4.81), a history of Hypertension (HR = 2.02; 95% CI = 1.42-2.89), Myocardial Infarction (HR= 1.72; 95% IC= 1.25-2.37), Dyslipidemia (HR = 1.68; 95% CI 1.30-2.17), duration of diabetes mellitus ≥ 10 years (HR = 1.46; 95% CI = 1.14-1.88) and Systolic Blood Pressure >149 mmHg (HR = 1.52; 95% CI = 1.02-2.24).
After a five-year follow-up, the cumulative incidence of CKD is concordant with rates described in Spain and other countries. Albuminuria ≥ 300 mg/g and age over 74 years were the risk factors more strongly associated with developing CKD (Stage 3-5). Blood Pressure, lipid and albuminuria control could reduce CKD incidence of CKD in patients with T2DM.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0122030</identifier><identifier>PMID: 25856231</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age Factors ; Aged ; Albuminuria - epidemiology ; Blood pressure ; Cholesterol ; Chronic kidney failure ; Cohort Studies ; Complications and side effects ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Dyslipidemia ; Glucose ; Health care ; Health risks ; Heart attacks ; Hemoglobin ; Hospitals ; Humans ; Hypertension ; Incidence ; Kidney diseases ; Kidneys ; Lipids ; Lipoproteins ; Meta-analysis ; Metabolic disorders ; Middle Aged ; Mortality ; Myocardial infarction ; Patients ; Preventive medicine ; Prospective Studies ; Public health ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - etiology ; Risk analysis ; Risk Assessment - methods ; Risk Factors ; Spain - epidemiology ; Statistics, Nonparametric ; Systematic review ; Time Factors ; Type 2 diabetes</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0122030-e0122030</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Salinero-Fort et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Salinero-Fort et al 2015 Salinero-Fort et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-82de9ec53cb205a1beb805450261e50188222a6b48906d47ae3e65e3e946d1e53</citedby><cites>FETCH-LOGICAL-c692t-82de9ec53cb205a1beb805450261e50188222a6b48906d47ae3e65e3e946d1e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391715/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391715/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25856231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mischak, Harald</contributor><creatorcontrib>Salinero-Fort, Miguel A</creatorcontrib><creatorcontrib>San Andrés-Rebollo, Francisco J</creatorcontrib><creatorcontrib>Carmen de Burgos-Lunar</creatorcontrib><creatorcontrib>Gómez-Campelo, Paloma</creatorcontrib><creatorcontrib>Chico-Moraleja, Rosa M</creatorcontrib><creatorcontrib>López de Andrés, Ana</creatorcontrib><creatorcontrib>Jiménez-García, Rodrigo</creatorcontrib><creatorcontrib>Group, MADIABETES</creatorcontrib><creatorcontrib>MADIABETES Group</creatorcontrib><title>Five-year incidence of chronic kidney disease (stage 3-5) and associated risk factors in a Spanish cohort: the MADIABETES Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the incidence rate of Chronic Kidney Disease (CKD) stage 3-5 (persistent decreased kidney function under 60 mL/min per 1.73 m2) among patients with type 2 diabetes over five years, to identify the risk factors associated with CKD, and develop a risk table to predict five-year CKD stage 3-5 risk stratification for clinical use.
The MADIABETES Study is a prospective cohort study of 3,443 outpatients with type 2 diabetes mellitus, sampled from 56 primary health care centers (131 general practitioners) in Madrid (Spain).
The cumulative incidence of CKD stage 3-5 at five-years was 10.23% (95% CI = 9.12-11.44) and the incidence density was 2.07 (95% CI = 1.83-2.33) cases per 1,000 patient-months or 2.48 (95% CI = 2.19-2.79) cases per 100 patient-years. The highest hazard ratio (HR) for developing CKD stage 3-5 was albuminuria ≥ 300 mg/g (HR = 4.57; 95% CI= 2.46-8.48). Furthermore, other variables with a high HR were age over 74 years (HR = 3.20; 95% CI = 2.13-4.81), a history of Hypertension (HR = 2.02; 95% CI = 1.42-2.89), Myocardial Infarction (HR= 1.72; 95% IC= 1.25-2.37), Dyslipidemia (HR = 1.68; 95% CI 1.30-2.17), duration of diabetes mellitus ≥ 10 years (HR = 1.46; 95% CI = 1.14-1.88) and Systolic Blood Pressure >149 mmHg (HR = 1.52; 95% CI = 1.02-2.24).
After a five-year follow-up, the cumulative incidence of CKD is concordant with rates described in Spain and other countries. Albuminuria ≥ 300 mg/g and age over 74 years were the risk factors more strongly associated with developing CKD (Stage 3-5). Blood Pressure, lipid and albuminuria control could reduce CKD incidence of CKD in patients with T2DM.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Albuminuria - epidemiology</subject><subject>Blood pressure</subject><subject>Cholesterol</subject><subject>Chronic kidney failure</subject><subject>Cohort Studies</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Dyslipidemia</subject><subject>Glucose</subject><subject>Health care</subject><subject>Health risks</subject><subject>Heart attacks</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Meta-analysis</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Patients</subject><subject>Preventive medicine</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Risk analysis</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Statistics, Nonparametric</subject><subject>Systematic review</subject><subject>Time Factors</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01vEzEQhlcIREvhHyCwhITaQ4I_dr27HJBCSSFSUSVSuFpeezbrdmMH21uRE38dh6RVg3pAlvz5zDv2eCbLXhI8Jqwk767c4K3sxytnYYwJpZjhR9khqRkd8bR4fG9-kD0L4QrjglWcP80OaFEVnDJymP0-MzcwWoP0yFhlNFgFyLVIdd5Zo9C10RbWSJsAMgA6DlEuALFRcYKk1UiG4JSRETTyJlyjVqrofEhaSKL5SloTOqRc53x8j2IH6Ovk02zycXo5naN5HPT6efaklX2AF7vxKPt-Nr08_TI6v_g8O52cjxSvaRxVVEMNqmCqobiQpIGmwkVeYMoJFJhUFaVU8iavasx1XkpgwIvU1TnXiWBH2eut7qp3QexiFwThJcWJKUgiZltCO3klVt4spV8LJ434u-H8QkgfjepBkIYT1lJGpS7zplSVUnXN65LUgCtoyqT1YedtaJagFdjoZb8nun9iTScW7kbkrCYl2Vz3eCfg3c8BQhRLExT0vbTghu29OaGM1Ql98w_68Ot21EKmBxjbuuRXbUTFJKcpTyqSb9yOH6BS07A0KiVaa9L-nsHJnkFiIvyKCzmEIGbzb__PXvzYZ9_eYzuQfeyC64donA37YL4FlXcheGjvgkyw2NTJbTTEpk7Erk6S2av7H3RndFsY7A_8QQqm</recordid><startdate>20150409</startdate><enddate>20150409</enddate><creator>Salinero-Fort, Miguel A</creator><creator>San Andrés-Rebollo, Francisco J</creator><creator>Carmen de Burgos-Lunar</creator><creator>Gómez-Campelo, Paloma</creator><creator>Chico-Moraleja, Rosa M</creator><creator>López de Andrés, Ana</creator><creator>Jiménez-García, Rodrigo</creator><creator>Group, MADIABETES</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150409</creationdate><title>Five-year incidence of chronic kidney disease (stage 3-5) and associated risk factors in a Spanish cohort: the MADIABETES Study</title><author>Salinero-Fort, Miguel A ; San Andrés-Rebollo, Francisco J ; Carmen de Burgos-Lunar ; Gómez-Campelo, Paloma ; Chico-Moraleja, Rosa M ; López de Andrés, Ana ; Jiménez-García, Rodrigo ; Group, MADIABETES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-82de9ec53cb205a1beb805450261e50188222a6b48906d47ae3e65e3e946d1e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Albuminuria - epidemiology</topic><topic>Blood pressure</topic><topic>Cholesterol</topic><topic>Chronic kidney failure</topic><topic>Cohort Studies</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Dyslipidemia</topic><topic>Glucose</topic><topic>Health care</topic><topic>Health risks</topic><topic>Heart attacks</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Meta-analysis</topic><topic>Metabolic disorders</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Patients</topic><topic>Preventive medicine</topic><topic>Prospective Studies</topic><topic>Public health</topic><topic>Renal Insufficiency, Chronic - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salinero-Fort, Miguel A</au><au>San Andrés-Rebollo, Francisco J</au><au>Carmen de Burgos-Lunar</au><au>Gómez-Campelo, Paloma</au><au>Chico-Moraleja, Rosa M</au><au>López de Andrés, Ana</au><au>Jiménez-García, Rodrigo</au><au>Group, MADIABETES</au><au>Mischak, Harald</au><aucorp>MADIABETES Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Five-year incidence of chronic kidney disease (stage 3-5) and associated risk factors in a Spanish cohort: the MADIABETES Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-09</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0122030</spage><epage>e0122030</epage><pages>e0122030-e0122030</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the incidence rate of Chronic Kidney Disease (CKD) stage 3-5 (persistent decreased kidney function under 60 mL/min per 1.73 m2) among patients with type 2 diabetes over five years, to identify the risk factors associated with CKD, and develop a risk table to predict five-year CKD stage 3-5 risk stratification for clinical use.
The MADIABETES Study is a prospective cohort study of 3,443 outpatients with type 2 diabetes mellitus, sampled from 56 primary health care centers (131 general practitioners) in Madrid (Spain).
The cumulative incidence of CKD stage 3-5 at five-years was 10.23% (95% CI = 9.12-11.44) and the incidence density was 2.07 (95% CI = 1.83-2.33) cases per 1,000 patient-months or 2.48 (95% CI = 2.19-2.79) cases per 100 patient-years. The highest hazard ratio (HR) for developing CKD stage 3-5 was albuminuria ≥ 300 mg/g (HR = 4.57; 95% CI= 2.46-8.48). Furthermore, other variables with a high HR were age over 74 years (HR = 3.20; 95% CI = 2.13-4.81), a history of Hypertension (HR = 2.02; 95% CI = 1.42-2.89), Myocardial Infarction (HR= 1.72; 95% IC= 1.25-2.37), Dyslipidemia (HR = 1.68; 95% CI 1.30-2.17), duration of diabetes mellitus ≥ 10 years (HR = 1.46; 95% CI = 1.14-1.88) and Systolic Blood Pressure >149 mmHg (HR = 1.52; 95% CI = 1.02-2.24).
After a five-year follow-up, the cumulative incidence of CKD is concordant with rates described in Spain and other countries. Albuminuria ≥ 300 mg/g and age over 74 years were the risk factors more strongly associated with developing CKD (Stage 3-5). Blood Pressure, lipid and albuminuria control could reduce CKD incidence of CKD in patients with T2DM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25856231</pmid><doi>10.1371/journal.pone.0122030</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0122030-e0122030 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1672094651 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Factors Aged Albuminuria - epidemiology Blood pressure Cholesterol Chronic kidney failure Cohort Studies Complications and side effects Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Dyslipidemia Glucose Health care Health risks Heart attacks Hemoglobin Hospitals Humans Hypertension Incidence Kidney diseases Kidneys Lipids Lipoproteins Meta-analysis Metabolic disorders Middle Aged Mortality Myocardial infarction Patients Preventive medicine Prospective Studies Public health Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Risk analysis Risk Assessment - methods Risk Factors Spain - epidemiology Statistics, Nonparametric Systematic review Time Factors Type 2 diabetes |
| title | Five-year incidence of chronic kidney disease (stage 3-5) and associated risk factors in a Spanish cohort: the MADIABETES Study |
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