T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols

Mucosal tissues are critical immune effector sites containing complex populations of leukocytes in a tissue microenvironment that remains incompletely understood. We identify and quantify in human distal colorectal tissue absolute mucosal CD3+ lymphocytes, including CD4+ and CD8+ subsets, by direct...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0122723-e0122723
Hauptverfasser:	Preza, Gloria Cuevas, Yang, Otto O, Elliott, Julie, Anton, Peter A, Ochoa, Maria T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS CD3 antigen CD4 antigen CD8 antigen Cell Count Cell Separation - methods Collagen Collagenase Colon Compartments Cytometry Data recovery Flow Cytometry Fluorescent Antibody Technique Functional testing HIV Human immunodeficiency virus Humans Immunofluorescence Immunohistochemistry Intestinal Mucosa - immunology Intestine, Large - immunology Leukocytes Lymphocytes Lymphocytes T Mucosal immunity Phenotyping Practice guidelines (Medicine) Rectum T-Lymphocyte Subsets - immunology Tissues
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