Peripheral blood mononuclear cells HIV DNA levels impact intermittently on neurocognition

To determine the contribution of peripheral blood mononuclear cells' (PBMCs) HIV DNA levels to HIV-associated dementia (HAD) and non-demented HIV-associated neurocognitive disorders (HAND) in chronically HIV-infected adults with long-term viral suppression on combined antiretroviral treatment (...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0120488-e0120488
Hauptverfasser:	Cysique, Lucette A, Hey-Cunningham, William J, Dermody, Nadene, Chan, Phillip, Brew, Bruce J, Koelsch, Kersten K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Adults AIDS Analysis Anti-HIV Agents - pharmacology Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Blood Brain research Cerebrospinal fluid Chronic infection Cognition Cognition - drug effects Cognitive ability Complications and side effects Dementia Dementia - blood Dementia - physiopathology Dementia - virology Dementia disorders Deoxyribonucleic acid DNA DNA, Viral - blood Drug therapy Female Health aspects HIV HIV - drug effects HIV - physiology HIV infections Hospitals Human immunodeficiency virus Humans Infections Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Medical research Middle Aged Nervous system Neurology Neuropsychology Neurosciences Pathogenesis Peripheral blood mononuclear cells Plasma Ribonucleic acid Risk factors RNA RNA, Viral - blood Studies Traumatic brain injury Viral Load - drug effects
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Zusammenfassung:	To determine the contribution of peripheral blood mononuclear cells' (PBMCs) HIV DNA levels to HIV-associated dementia (HAD) and non-demented HIV-associated neurocognitive disorders (HAND) in chronically HIV-infected adults with long-term viral suppression on combined antiretroviral treatment (cART). Eighty adults with chronic HIV infection on cART (>97% with plasma and CSF HIV RNA
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0120488