Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling

The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1α in the pathogenesis of DN. Rat glomerular mesangial cells (R...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0125176-e0125176
Hauptverfasser:	Guo, Kaifeng, Lu, Junxi, Huang, Yan, Wu, Mian, Zhang, Lei, Yu, Haoyong, Zhang, Mingliang, Bao, Yuqian, He, John Cijiang, Chen, Haibing, Jia, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2'-Deoxyguanosine 8-Hydroxydeoxyguanosine Animals Apoptosis Bioindicators Biomarkers Biomarkers - metabolism Biosynthesis Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Diabetes Diabetes mellitus Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic nephropathy Dynamins - genetics Dynamins - metabolism Endocrinology Gene expression Gene Expression Regulation Glucose Glucose - metabolism Glucose - pharmacology Hospitals Humans Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - pathology Hypertrophy Inhibition Kidneys Laboratory animals Male Mesangial cells Mesangial Cells - drug effects Mesangial Cells - metabolism Mesangial Cells - pathology Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial Dynamics - drug effects Mitochondrial Dynamics - genetics Morphology Nephropathy Oxidative Stress Oxygen Pathogenesis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Plasmids - chemistry Plasmids - metabolism Primary Cell Culture Proteins Proteinuria Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Renal cortex Rodents Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Transfection
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