Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis

In eukaryotes, post-transcriptional regulation of gene expression has a key role in many cellular and developmental processes. Spermatogenesis involves a complex developmental program that includes changes in cell cycle dynamics and dramatic cellular remodeling. Translational control is critical for...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0122519-e0122519
Hauptverfasser:	Ghosh, Sanjay, Lasko, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Cell cycle Chromosomes - physiology Cysts Cytokinesis Cytokinesis - physiology Developmental stages Divisions Drosophila Drosophila - metabolism Drosophila melanogaster Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Drosophila Proteins - metabolism Elongation Eukaryotes Eukaryotic Initiation Factor-4E - antagonists & inhibitors Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Eukaryotic Initiation Factor-4G - antagonists & inhibitors Eukaryotic Initiation Factor-4G - genetics Eukaryotic Initiation Factor-4G - metabolism Fertility Function analysis Gene expression Gene regulation Genomics Germ cells Germ Cells - growth & development Initiation factor eIF-4E Initiation factor eIF-4G Initiation factors Insects Male Meiosis Post-transcription Proteins Ribonucleic acid RNA RNA Interference RNA, Small Interfering - metabolism RNA-mediated interference Somatic cells Sperm Spermatocytes Spermatocytes - metabolism Spermatogenesis Stem cells Testes Testis - metabolism Transcription (Genetics) Translation (Genetics)
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