TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration

Cytokine-dependent activation of fibroblasts to myofibroblasts, a key event in fibrosis, is accompanied by phenotypic changes with increased secretory and contractile properties dependent on increased energy utilization, yet changes in the energetic profile of these cells are not fully described. We...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123046-e0123046
Hauptverfasser:	Negmadjanov, Ulugbek, Godic, Zarko, Rizvi, Farhan, Emelyanova, Larisa, Ross, Gracious, Richards, John, Holmuhamedov, Ekhson L, Jahangir, Arshad
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adenine Aging Animals Anion channels Blotting, Western Carbon dioxide Cell culture Cell Differentiation - drug effects Cell Respiration - physiology Cells, Cultured Confocal microscopy Cytokines Deoxyribonucleic acid Differentiation DNA Electron transport Energy utilization Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Genetic transformation Glucose Heart Immunoenzyme Techniques Immunoglobulins Ion channels Lasers Membrane potential Metabolism Mice Microscopy Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Mitochondrial Proteins - metabolism Muscle contraction Muscles NIH 3T3 Cells Oxygen Oxygen consumption Penicillin Proteins Respiration Respirometry RNA, Messenger - metabolism Smooth muscle Transformation Transformations (mathematics) Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Transporter Western blotting Wound healing
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