The effects of 1α, 25-dihydroxyvitamin D3 and transforming growth factor-β3 on bone development in an ex vivo organotypic culture system of embryonic chick femora

Transforming growth factor-beta3 (TGF-β3) and 1α,25-dihydroxyvitamin D3 (1α,25 (OH) 2D3) are essential factors in chondrogenesis and osteogenesis respectively. These factors also play a fundamental role in the developmental processes and the maintenance of skeletal integrity, but their respective di...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0121653-e0121653
Hauptverfasser:	Smith, Emma L, Rashidi, Hassan, Kanczler, Janos M, Shakesheff, Kevin M, Oreffo, Richard O C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biomarkers - metabolism Biomedical materials Bone growth Cell culture Chick Embryo Chondrogenesis Chondrogenesis - drug effects Collagen Collagen Type I - genetics Collagen Type I - metabolism Computed tomography Embryogenesis Femur Femur - cytology Femur - drug effects Femur - growth & development Femur - metabolism Gene Expression Histology Immunohistochemistry Mesenchymal stem cells Metabolism Modulation Osteogenesis Osteogenesis - drug effects Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Tissue Culture Techniques Transforming Growth Factor beta3 - pharmacology Transforming growth factor-b1 Vitamin D - analogs & derivatives Vitamin D - pharmacology Vitamin D3
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