The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid

Recently, photodynamic therapy using 5-aminolevulinic acid (ALA-PDT) has been widely used in cancer therapy. ALA administration results in tumor-selective accumulation of the photosensitizer protoporphyrin IX (PpIX) via the heme biosynthetic pathway. Although ALA-PDT has selectivity for tumor cells,...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0122351-e0122351
Hauptverfasser:	Hayashi, Maiko, Fukuhara, Hideo, Inoue, Keiji, Shuin, Taro, Hagiya, Yuichiro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acids Aminolevulinic acid Aminolevulinic Acid - pharmacology Biosynthesis Biotechnology Cancer Cancer therapies Cation Transport Proteins - metabolism Cell Line, Tumor Citric acid Glucose Health aspects Heme Heme - metabolism Humans Iron Iron - metabolism MCF-7 Cells Medical schools Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Photochemotherapy Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacology Physiological aspects Protoporphyrin Protoporphyrin IX Protoporphyrins - metabolism Sensitivity and Specificity Side effects Sodium Substrates Tumor cells Tumors Urology
Online-Zugang:	Volltext
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