No-needle, single-visit adult male circumcision with Unicirc: a multi-centre field trial
Voluntary medical male circumcision (VMMC) is a priority HIV preventive intervention. Current adult circumcision methods need improvement. Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed...
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| creator | Millard, Peter S Goldstuck, Norman D |
| description | Voluntary medical male circumcision (VMMC) is a priority HIV preventive intervention. Current adult circumcision methods need improvement.
Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed up at 1 and 4 weeks.
We circumcised 110 healthy volunteers. Two men complained of transient burning pain during circumcision, but none required injectable anaesthesia. Median blood loss was 1ml and median procedure time was 9.0 min. There were 7 (6.3%) moderate complications (5 (4.5%) post-operative bleeds requiring suture and 2 (1.8%) post-operative infections) affecting 7 men. No men experienced significant wound dehiscence. 90.4% of men were fully healed at 4 weeks of follow-up and all were highly satisfied.
Use of topical anaesthesia obviates the need for injectable anesthetic and makes the Unicirc procedure nearly painless. Unicirc is rapid, easy to learn, heals by primary intention with excellent cosmetic results, obviates the need for a return visit for device removal, and is potentially cheaper and safer than other methods. Use of this method will greatly facilitate scale-up of mass circumcision programs.
ClinicalTrials.gov NCT02091726. |
| doi_str_mv | 10.1371/journal.pone.0121686 |
| format | Article |
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Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed up at 1 and 4 weeks.
We circumcised 110 healthy volunteers. Two men complained of transient burning pain during circumcision, but none required injectable anaesthesia. Median blood loss was 1ml and median procedure time was 9.0 min. There were 7 (6.3%) moderate complications (5 (4.5%) post-operative bleeds requiring suture and 2 (1.8%) post-operative infections) affecting 7 men. No men experienced significant wound dehiscence. 90.4% of men were fully healed at 4 weeks of follow-up and all were highly satisfied.
Use of topical anaesthesia obviates the need for injectable anesthetic and makes the Unicirc procedure nearly painless. Unicirc is rapid, easy to learn, heals by primary intention with excellent cosmetic results, obviates the need for a return visit for device removal, and is potentially cheaper and safer than other methods. Use of this method will greatly facilitate scale-up of mass circumcision programs.
ClinicalTrials.gov NCT02091726.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0121686</identifier><identifier>PMID: 25822727</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesives ; Adult ; Anesthesia ; Anesthetics, Local - administration & dosage ; Bleeding ; Burning ; Circumcision ; Circumcision, Male - adverse effects ; Circumcision, Male - instrumentation ; Circumcision, Male - methods ; Clinical trials ; Complications ; Dehiscence ; Disease prevention ; Health aspects ; HIV ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human immunodeficiency virus ; Humans ; Infection ; Lidocaine ; Male ; Medical services ; Men ; Minimally Invasive Surgical Procedures - adverse effects ; Minimally Invasive Surgical Procedures - instrumentation ; Minimally Invasive Surgical Procedures - methods ; Motivation ; Pain ; Postoperative Hemorrhage - etiology ; Prilocaine ; Skin ; South Africa ; Studies ; Surgical Wound Infection - etiology ; Time Factors ; Tissue Adhesives - administration & dosage ; Topical analgesics ; Wound Healing ; Young Adult</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0121686-e0121686</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Millard, Goldstuck. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Millard, Goldstuck 2015 Millard, Goldstuck</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c717t-d66ee9338019727660c73207bbe0eed07129eb7f92ab21ccc02aaf38d1d086183</citedby><cites>FETCH-LOGICAL-c717t-d66ee9338019727660c73207bbe0eed07129eb7f92ab21ccc02aaf38d1d086183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379010/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379010/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25822727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hills, Robert K</contributor><creatorcontrib>Millard, Peter S</creatorcontrib><creatorcontrib>Goldstuck, Norman D</creatorcontrib><title>No-needle, single-visit adult male circumcision with Unicirc: a multi-centre field trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Voluntary medical male circumcision (VMMC) is a priority HIV preventive intervention. Current adult circumcision methods need improvement.
Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed up at 1 and 4 weeks.
We circumcised 110 healthy volunteers. Two men complained of transient burning pain during circumcision, but none required injectable anaesthesia. Median blood loss was 1ml and median procedure time was 9.0 min. There were 7 (6.3%) moderate complications (5 (4.5%) post-operative bleeds requiring suture and 2 (1.8%) post-operative infections) affecting 7 men. No men experienced significant wound dehiscence. 90.4% of men were fully healed at 4 weeks of follow-up and all were highly satisfied.
Use of topical anaesthesia obviates the need for injectable anesthetic and makes the Unicirc procedure nearly painless. Unicirc is rapid, easy to learn, heals by primary intention with excellent cosmetic results, obviates the need for a return visit for device removal, and is potentially cheaper and safer than other methods. Use of this method will greatly facilitate scale-up of mass circumcision programs.
ClinicalTrials.gov NCT02091726.</description><subject>Adhesives</subject><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Bleeding</subject><subject>Burning</subject><subject>Circumcision</subject><subject>Circumcision, Male - adverse effects</subject><subject>Circumcision, Male - instrumentation</subject><subject>Circumcision, Male - methods</subject><subject>Clinical trials</subject><subject>Complications</subject><subject>Dehiscence</subject><subject>Disease prevention</subject><subject>Health aspects</subject><subject>HIV</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infection</subject><subject>Lidocaine</subject><subject>Male</subject><subject>Medical services</subject><subject>Men</subject><subject>Minimally Invasive Surgical Procedures - adverse effects</subject><subject>Minimally Invasive Surgical Procedures - instrumentation</subject><subject>Minimally Invasive Surgical Procedures - methods</subject><subject>Motivation</subject><subject>Pain</subject><subject>Postoperative Hemorrhage - etiology</subject><subject>Prilocaine</subject><subject>Skin</subject><subject>South Africa</subject><subject>Studies</subject><subject>Surgical Wound Infection - etiology</subject><subject>Time Factors</subject><subject>Tissue Adhesives - administration & dosage</subject><subject>Topical analgesics</subject><subject>Wound Healing</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk22L1DAQx4so3nn6DUQLB6Jg1zy0SeoL4Th8WDg8UE98F9J0upslbdYmPfXbm-72jq3cC8mLhMlv_jOZzCTJU4wWmHL8ZuOGvlN2sXUdLBAmmAl2LznGJSUZI4jePzgfJY-83yBUUMHYw-SIFIIQTvhx8uOzyzqA2sLr1JtuZSG7Nt6EVNWDDWmrLKTa9HpodTS7Lv1lwjq96sxofJuqtI2YyTR0oYe0MWDrNPRG2cfJg0ZZD0-m_SS5-vD-2_mn7OLy4_L87CLTHPOQ1YwBlJQKhMuYEGNIc0oQrypAMS3EMSmh4k1JVEWw1hoRpRoqalwjwbCgJ8nzve7WOi-noniJGeOsKFGBI7HcE7VTG7ntTav6P9IpI3cG16-k6oPRFiTTQvEiL-qy1Dk0TPCc6bwQmFeKxoBR690UbahaqHfPVnYmOr_pzFqu3LXMKS8RRlHg5STQu58D-CBb4zVYqzpwwy5vQShjeRHR03_Qu183Uav4VdJ0jYtx9Sgqz3JcIspoOWot7qDiqqE1OnZQY6J95vBq5hCZAL_DSg3ey-XXL__PXn6fsy8O2DUoG9be2SHE3vJzMN-Dunfe99DcFhkjOQ7ATTXkOAByGoDo9uzwg26dbjqe_gVZKf8A</recordid><startdate>20150330</startdate><enddate>20150330</enddate><creator>Millard, Peter S</creator><creator>Goldstuck, Norman D</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150330</creationdate><title>No-needle, single-visit adult male circumcision with Unicirc: a multi-centre field trial</title><author>Millard, Peter S ; Goldstuck, Norman D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c717t-d66ee9338019727660c73207bbe0eed07129eb7f92ab21ccc02aaf38d1d086183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesives</topic><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthetics, Local - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Millard, Peter S</au><au>Goldstuck, Norman D</au><au>Hills, Robert K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No-needle, single-visit adult male circumcision with Unicirc: a multi-centre field trial</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-30</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0121686</spage><epage>e0121686</epage><pages>e0121686-e0121686</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Voluntary medical male circumcision (VMMC) is a priority HIV preventive intervention. Current adult circumcision methods need improvement.
Field trial in 3 primary care centres. Minimally invasive VMMC using the Unicirc instrument following topical lidocaine/prilocaine anesthetic. Men were followed up at 1 and 4 weeks.
We circumcised 110 healthy volunteers. Two men complained of transient burning pain during circumcision, but none required injectable anaesthesia. Median blood loss was 1ml and median procedure time was 9.0 min. There were 7 (6.3%) moderate complications (5 (4.5%) post-operative bleeds requiring suture and 2 (1.8%) post-operative infections) affecting 7 men. No men experienced significant wound dehiscence. 90.4% of men were fully healed at 4 weeks of follow-up and all were highly satisfied.
Use of topical anaesthesia obviates the need for injectable anesthetic and makes the Unicirc procedure nearly painless. Unicirc is rapid, easy to learn, heals by primary intention with excellent cosmetic results, obviates the need for a return visit for device removal, and is potentially cheaper and safer than other methods. Use of this method will greatly facilitate scale-up of mass circumcision programs.
ClinicalTrials.gov NCT02091726.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25822727</pmid><doi>10.1371/journal.pone.0121686</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; Public Library of Science; PubMed Central; EZB Electronic Journals Library |
| subjects | Adhesives Adult Anesthesia Anesthetics, Local - administration & dosage Bleeding Burning Circumcision Circumcision, Male - adverse effects Circumcision, Male - instrumentation Circumcision, Male - methods Clinical trials Complications Dehiscence Disease prevention Health aspects HIV HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Humans Infection Lidocaine Male Medical services Men Minimally Invasive Surgical Procedures - adverse effects Minimally Invasive Surgical Procedures - instrumentation Minimally Invasive Surgical Procedures - methods Motivation Pain Postoperative Hemorrhage - etiology Prilocaine Skin South Africa Studies Surgical Wound Infection - etiology Time Factors Tissue Adhesives - administration & dosage Topical analgesics Wound Healing Young Adult |
| title | No-needle, single-visit adult male circumcision with Unicirc: a multi-centre field trial |
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