Polysialylation of NCAM characterizes the proliferation period of contractile elements during postnatal development of the epididymis

Polysialic acid (polySia) attached to the neural cell adhesion molecule (NCAM) regulates inter alia the proliferation and differentiation via the interactions with neurotrophins. Since in postnatal epididymis neurotrophins and their receptors like the Low-Affinity Nerve Growth Factor Receptor p75 an...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0123960-e0123960
Hauptverfasser:	Simon, Peter, Feuerstacke, Caroline, Kaese, Miriam, Saboor, Farhan, Middendorff, Ralf, Galuska, Sebastian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Biochemistry Biology Brain-derived neurotrophic factor Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Differentiation - physiology Cell division Cell proliferation Cell Proliferation - physiology Collagen Collagen - metabolism Contractility Endocytosis Epididymis Epididymis - growth & development Epididymis - metabolism Female Growth factors Immunoglobulins Laboratory animals Male Mice Molecular chains Muscle contraction Muscle Contraction - physiology Muscles Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - physiology Nerve growth factor Nerve Growth Factors - metabolism Neural cell adhesion molecule Neural Cell Adhesion Molecules - metabolism Neurotrophic factors Polymerization Polysialic acid Polysialylation Receptors Reproductive system Sialic Acids - metabolism Sialyltransferases - metabolism Smooth muscle Up-Regulation - physiology Vas deferens
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