Oligodendrocyte birth and death following traumatic brain injury in adult mice

Oligodendrocytes are responsible for producing and maintaining myelin throughout the CNS. One of the pathological features observed following traumatic brain injury (TBI) is the progressive demyelination and degeneration of axons within white matter tracts. While the effect of TBI on axonal health h...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121541-e0121541
Hauptverfasser:	Dent, Krista A, Christie, Kimberly J, Bye, Nicole, Basrai, Harleen S, Turbic, Alisa, Habgood, Mark, Cate, Holly S, Turnley, Ann M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Axons Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Brain Brain injuries Brain Injuries - pathology Cell Death Cell Lineage Cell proliferation Cell survival Central nervous system Corpus callosum Cortex Cortex (motor) Cytokines Degeneration Demyelination Female Gene expression Head injuries Immunoreactivity Influence Male Metabolism Metabolites Mice Mice, Inbred C57BL Myelin Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurodegeneration Neurosciences Olig2 protein Oligodendrocyte Transcription Factor 2 Oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - pathology Oxidative stress Pathology Progeny Proteins Rodents Spinal cord Studies Substantia alba Traumatic brain injury
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