Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Sirtuin 1 (Sirt1) is a class III histone deacetylase (HDAC) that modulates gene expression and is involved in the regulation of proinflammatory cytokines. Interleukin-23 (IL-23) is produced by activated macrophages and dendritic cells and could fuel the progression of rheumatoid arthritis (RA). The...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119981-e0119981
Hauptverfasser:	Wendling, Daniel, Abbas, Wasim, Godfrin-Valnet, Marie, Kumar, Amit, Guillot, Xavier, Khan, Kashif Aziz, Vidon, Claire, Coquard, Laurie, Toussirot, Eric, Prati, Clément, Herbein, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - pathology Autoimmune diseases Biomarkers - blood Blood Case-Control Studies Comparative analysis Correlation Cytokines Dendritic cells Disease Disease Progression Epigenetics Female Fibroblasts Gene expression Histone deacetylase Homeostasis Humans Inflammation Interleukin 23 Interleukin 6 Interleukin-23 Subunit p19 - blood Interleukin-6 - blood Interleukins Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Macrophages Male Middle Aged Nuclear fuels Pathogens Patients Peripheral blood mononuclear cells Rheumatoid arthritis Rheumatoid factor Rheumatology SIRT1 protein Sirtuin 1 - blood Tumor necrosis factor-TNF Western blotting
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