A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)

Dopaminergic neurons in the substantia nigra pars compacta (SNpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled by nuclear receptor related 1 (Nurr1). Nurr1 is also expressed in astrocytes a...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121072-e0121072
Hauptverfasser:	Smith, Gaynor A, Rocha, Emily M, Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R, Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J, Isacson, Ole
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Astrocytes Brain Brain research Cytokines Degeneration Disease Models, Animal Dopamine Dopamine - biosynthesis Dopamine receptors Dopamine transporter Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Double-stranded RNA Gene Expression Genes Genotype & phenotype Glial cell line-derived neurotrophic factor Glial fibrillary acidic protein Health aspects Imidazoles - administration & dosage Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Injection Interleukin 6 Intermediate filament proteins Kinases Male Medical schools Microglia Microglia - metabolism Microglia - pathology Movement disorders Mutation Nerve Degeneration - drug therapy Nerve Degeneration - pathology Neurodegeneration Neurodegenerative diseases Neurons Neuroprotection Neuroprotection - drug effects Neurotoxicity Nuclear Receptor Subfamily 4, Group A, Member 2 - agonists Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics Nuclear receptors Nurr1 protein Oxidopamine - toxicity Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - metabolism Parkinson Disease, Secondary - pathology Parkinson's disease Pars Compacta - drug effects Pars Compacta - metabolism Pathogenesis Phenotypes Poly I-C - administration & dosage Polyinosinic:polycytidylic acid Priming Pyridines - administration & dosage Rats RNA, Double-Stranded Rodents Staining Substantia nigra TLR3 protein Toll-Like Receptor 3 - biosynthesis Toll-Like Receptor 3 - genetics Toll-like receptors Transcription
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