Human dendritic cell DC-SIGN and TLR-2 mediate complementary immune regulatory activities in response to Lactobacillus rhamnosus JB-1

The microbiota is required for optimal host development and ongoing immune homeostasis. Lactobacilli are common inhabitants of the mammalian large intestine and immunoregulatory effects have been described for certain, but not all, strains. The mechanisms underpinning these protective effects are be...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120261-e0120261
Hauptverfasser:	Konieczna, Patrycja, Schiavi, Elisa, Ziegler, Mario, Groeger, David, Healy, Selena, Grant, Ray, O'Mahony, Liam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Antibiotics Antibodies Asthma Bacteria CD80 antigen CD86 antigen Cell activation Cell Adhesion Molecules - immunology Cells, Cultured Commensals Cost analysis Cytokines Cytokines - metabolism DC-SIGN protein Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Foxp3 protein Histamine Homeostasis Humans Immune system Immunologic Factors - pharmacology Immunoregulation Inflammation Interleukin 10 Interleukin 12 Internalization Intracellular Kinetics Lactobacilli Lactobacillus Lactobacillus acidophilus Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus rhamnosus - immunology Large intestine Lectins, C-Type - immunology Lymphocyte Activation - immunology Lymphocytes Microbiota Microbiota (Symbiotic organisms) Microscopy Molecular chains Monocytes Monocytes - cytology Monocytes - immunology Receptors Receptors, Cell Surface - immunology T cell receptors TLR2 protein Toll-Like Receptor 2 - immunology Toll-like receptors
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