Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP
This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. Observational study,...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-03, Vol.10 (3), p.e0122091-e0122091 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0122091 |
|---|---|
| container_issue | 3 |
| container_start_page | e0122091 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Muñoz-Hernandez, Rocio Vallejo-Vaz, Antonio J Sanchez Armengol, Angeles Moreno-Luna, Rafael Caballero-Eraso, Candela Macher, Hada C Villar, Jose Merino, Ana M Castell, Javier Capote, Francisco Stiefel, Pablo |
| description | This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy.
Observational study, before and after CPAP therapy.
We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process.
After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p |
| doi_str_mv | 10.1371/journal.pone.0122091 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1667159239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A421800717</galeid><doaj_id>oai_doaj_org_article_f5a4731f73a64aa8ac77df210182268c</doaj_id><sourcerecordid>A421800717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-4bcfd8a599659d2600b1232bec398cb9b092f9c41713518243bad7b088f321493</originalsourceid><addsrcrecordid>eNqNk1uL1DAUx4so7kW_gWhBEAVnzKVtmhdhGLwMLMzi7TWcpslMxzQZk3bZ9dObOt1lKvsgeUg4-Z3_yTknJ0meYTTHlOF3O9d7C2a-d1bNESYEcfwgOcWckllBEH14dD5JzkLYIZTTsigeJyckL3GeY3yatOsqdL6XXXOl0mCU2qewt05BGm5s7V2r3qbK1q7bKtOASXVvI-tsCrZOW_A_lQ-p08dM8xsGYp4ut2A3KqSgO-XT5eXi8knySIMJ6um4nyffP374tvw8u1h_Wi0XFzPJ8rKbZZXUdQk550XOa1IgVGFCSaUk5aWseIU40VxmmGGa45JktIKaVagsNSU44_Q8eXHQ3RsXxFipIHBRMJxzQgdidSBqBzux903M5UY4aMRfg_MbAb5rpFFC55AxijWjUGQAJUjGak0wipFJUcqo9X6M1letqqWynQczEZ3e2GYrNu5KZJQVHNEo8HoU8O5Xr0In2iZIZQxY5frDu3kR-4sj-vIf9P7sRmoDMYHGahfjykFULDKCS4QYZpGa30PFVau2kfFb6SbaJw5vJg6R6dR1t4E-BLH6-uX_2fWPKfvqiN0qMN02ONMP3yhMwewASu9C8ErfFRkjMUzFbTXEMBVinIro9vy4QXdOt2NA_wDCNAbI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1667159239</pqid></control><display><type>article</type><title>Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Muñoz-Hernandez, Rocio ; Vallejo-Vaz, Antonio J ; Sanchez Armengol, Angeles ; Moreno-Luna, Rafael ; Caballero-Eraso, Candela ; Macher, Hada C ; Villar, Jose ; Merino, Ana M ; Castell, Javier ; Capote, Francisco ; Stiefel, Pablo</creator><contributor>Yung, Wing-ho</contributor><creatorcontrib>Muñoz-Hernandez, Rocio ; Vallejo-Vaz, Antonio J ; Sanchez Armengol, Angeles ; Moreno-Luna, Rafael ; Caballero-Eraso, Candela ; Macher, Hada C ; Villar, Jose ; Merino, Ana M ; Castell, Javier ; Capote, Francisco ; Stiefel, Pablo ; Yung, Wing-ho</creatorcontrib><description>This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy.
Observational study, before and after CPAP therapy.
We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process.
After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p<0.01, and 69.60 ± 62.60 vs. 39.82 ± 22.14 U/μL, p<0.05, respectively) and VEGF levels increased (585.02 ± 246.06 vs. 641.11 ± 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p<0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together.
CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0122091</identifier><identifier>PMID: 25815511</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Apnea ; Biomarkers ; Biomarkers - blood ; Cardiovascular disease ; Cell-Derived Microparticles - pathology ; Comparative analysis ; Continuous Positive Airway Pressure ; Damage ; Deoxyribonucleic acid ; Diabetes ; DNA ; DNA - blood ; Doppler effect ; Endothelium ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Female ; Humans ; Hypertension ; Hypoxia ; In vivo methods and tests ; Male ; Microparticles ; Middle Aged ; Observational studies ; Patients ; Political aspects ; Restoration ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Therapy ; Thoracic surgery ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0122091-e0122091</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Muñoz-Hernandez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Muñoz-Hernandez et al 2015 Muñoz-Hernandez et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-4bcfd8a599659d2600b1232bec398cb9b092f9c41713518243bad7b088f321493</citedby><cites>FETCH-LOGICAL-c758t-4bcfd8a599659d2600b1232bec398cb9b092f9c41713518243bad7b088f321493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376903/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376903/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25815511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yung, Wing-ho</contributor><creatorcontrib>Muñoz-Hernandez, Rocio</creatorcontrib><creatorcontrib>Vallejo-Vaz, Antonio J</creatorcontrib><creatorcontrib>Sanchez Armengol, Angeles</creatorcontrib><creatorcontrib>Moreno-Luna, Rafael</creatorcontrib><creatorcontrib>Caballero-Eraso, Candela</creatorcontrib><creatorcontrib>Macher, Hada C</creatorcontrib><creatorcontrib>Villar, Jose</creatorcontrib><creatorcontrib>Merino, Ana M</creatorcontrib><creatorcontrib>Castell, Javier</creatorcontrib><creatorcontrib>Capote, Francisco</creatorcontrib><creatorcontrib>Stiefel, Pablo</creatorcontrib><title>Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy.
Observational study, before and after CPAP therapy.
We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process.
After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p<0.01, and 69.60 ± 62.60 vs. 39.82 ± 22.14 U/μL, p<0.05, respectively) and VEGF levels increased (585.02 ± 246.06 vs. 641.11 ± 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p<0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together.
CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.</description><subject>Adult</subject><subject>Apnea</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cell-Derived Microparticles - pathology</subject><subject>Comparative analysis</subject><subject>Continuous Positive Airway Pressure</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>DNA - blood</subject><subject>Doppler effect</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoxia</subject><subject>In vivo methods and tests</subject><subject>Male</subject><subject>Microparticles</subject><subject>Middle Aged</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Political aspects</subject><subject>Restoration</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Therapy</subject><subject>Thoracic surgery</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7kW_gWhBEAVnzKVtmhdhGLwMLMzi7TWcpslMxzQZk3bZ9dObOt1lKvsgeUg4-Z3_yTknJ0meYTTHlOF3O9d7C2a-d1bNESYEcfwgOcWckllBEH14dD5JzkLYIZTTsigeJyckL3GeY3yatOsqdL6XXXOl0mCU2qewt05BGm5s7V2r3qbK1q7bKtOASXVvI-tsCrZOW_A_lQ-p08dM8xsGYp4ut2A3KqSgO-XT5eXi8knySIMJ6um4nyffP374tvw8u1h_Wi0XFzPJ8rKbZZXUdQk550XOa1IgVGFCSaUk5aWseIU40VxmmGGa45JktIKaVagsNSU44_Q8eXHQ3RsXxFipIHBRMJxzQgdidSBqBzux903M5UY4aMRfg_MbAb5rpFFC55AxijWjUGQAJUjGak0wipFJUcqo9X6M1letqqWynQczEZ3e2GYrNu5KZJQVHNEo8HoU8O5Xr0In2iZIZQxY5frDu3kR-4sj-vIf9P7sRmoDMYHGahfjykFULDKCS4QYZpGa30PFVau2kfFb6SbaJw5vJg6R6dR1t4E-BLH6-uX_2fWPKfvqiN0qMN02ONMP3yhMwewASu9C8ErfFRkjMUzFbTXEMBVinIro9vy4QXdOt2NA_wDCNAbI</recordid><startdate>20150327</startdate><enddate>20150327</enddate><creator>Muñoz-Hernandez, Rocio</creator><creator>Vallejo-Vaz, Antonio J</creator><creator>Sanchez Armengol, Angeles</creator><creator>Moreno-Luna, Rafael</creator><creator>Caballero-Eraso, Candela</creator><creator>Macher, Hada C</creator><creator>Villar, Jose</creator><creator>Merino, Ana M</creator><creator>Castell, Javier</creator><creator>Capote, Francisco</creator><creator>Stiefel, Pablo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150327</creationdate><title>Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP</title><author>Muñoz-Hernandez, Rocio ; Vallejo-Vaz, Antonio J ; Sanchez Armengol, Angeles ; Moreno-Luna, Rafael ; Caballero-Eraso, Candela ; Macher, Hada C ; Villar, Jose ; Merino, Ana M ; Castell, Javier ; Capote, Francisco ; Stiefel, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-4bcfd8a599659d2600b1232bec398cb9b092f9c41713518243bad7b088f321493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Apnea</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Cell-Derived Microparticles - pathology</topic><topic>Comparative analysis</topic><topic>Continuous Positive Airway Pressure</topic><topic>Damage</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>DNA</topic><topic>DNA - blood</topic><topic>Doppler effect</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypoxia</topic><topic>In vivo methods and tests</topic><topic>Male</topic><topic>Microparticles</topic><topic>Middle Aged</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Political aspects</topic><topic>Restoration</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><topic>Therapy</topic><topic>Thoracic surgery</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muñoz-Hernandez, Rocio</creatorcontrib><creatorcontrib>Vallejo-Vaz, Antonio J</creatorcontrib><creatorcontrib>Sanchez Armengol, Angeles</creatorcontrib><creatorcontrib>Moreno-Luna, Rafael</creatorcontrib><creatorcontrib>Caballero-Eraso, Candela</creatorcontrib><creatorcontrib>Macher, Hada C</creatorcontrib><creatorcontrib>Villar, Jose</creatorcontrib><creatorcontrib>Merino, Ana M</creatorcontrib><creatorcontrib>Castell, Javier</creatorcontrib><creatorcontrib>Capote, Francisco</creatorcontrib><creatorcontrib>Stiefel, Pablo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muñoz-Hernandez, Rocio</au><au>Vallejo-Vaz, Antonio J</au><au>Sanchez Armengol, Angeles</au><au>Moreno-Luna, Rafael</au><au>Caballero-Eraso, Candela</au><au>Macher, Hada C</au><au>Villar, Jose</au><au>Merino, Ana M</au><au>Castell, Javier</au><au>Capote, Francisco</au><au>Stiefel, Pablo</au><au>Yung, Wing-ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-27</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0122091</spage><epage>e0122091</epage><pages>e0122091-e0122091</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy.
Observational study, before and after CPAP therapy.
We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process.
After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p<0.01, and 69.60 ± 62.60 vs. 39.82 ± 22.14 U/μL, p<0.05, respectively) and VEGF levels increased (585.02 ± 246.06 vs. 641.11 ± 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p<0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together.
CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25815511</pmid><doi>10.1371/journal.pone.0122091</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0122091-e0122091 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1667159239 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Apnea Biomarkers Biomarkers - blood Cardiovascular disease Cell-Derived Microparticles - pathology Comparative analysis Continuous Positive Airway Pressure Damage Deoxyribonucleic acid Diabetes DNA DNA - blood Doppler effect Endothelium Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Female Humans Hypertension Hypoxia In vivo methods and tests Male Microparticles Middle Aged Observational studies Patients Political aspects Restoration Sleep Sleep apnea Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - therapy Sleep disorders Therapy Thoracic surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood |
| title | Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obstructive%20sleep%20apnoea%20syndrome,%20endothelial%20function%20and%20markers%20of%20endothelialization.%20Changes%20after%20CPAP&rft.jtitle=PloS%20one&rft.au=Mu%C3%B1oz-Hernandez,%20Rocio&rft.date=2015-03-27&rft.volume=10&rft.issue=3&rft.spage=e0122091&rft.epage=e0122091&rft.pages=e0122091-e0122091&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0122091&rft_dat=%3Cgale_plos_%3EA421800717%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1667159239&rft_id=info:pmid/25815511&rft_galeid=A421800717&rft_doaj_id=oai_doaj_org_article_f5a4731f73a64aa8ac77df210182268c&rfr_iscdi=true |