A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody

The severity of influenza-related illness is mediated by many factors, including in vivo cell tropism, timing and magnitude of the immune response, and presence of pre-existing immunity. A direct way to study cell tropism and virus spread in vivo is with an influenza virus expressing a reporter gene...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121491
Hauptverfasser:	De Baets, Sarah, Verhelst, Judith, Van den Hoecke, Silvie, Smet, Anouk, Schotsaert, Michael, Job, Emma R, Roose, Kenny, Schepens, Bert, Fiers, Walter, Saelens, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Antigen presentation Antiviral Agents - administration & dosage Antiviral Agents - pharmacology CD11b antigen CD11c antigen Cells, Cultured Coding Dendritic cells Dendritic Cells - metabolism Dendritic Cells - virology Dimerization Dogs Epithelial cells Flow cytometry Genomes Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Health aspects Immune response Immune system Immunity In vivo methods and tests Infections Inflammation Influenza Influenza A Influenza A virus - drug effects Influenza A virus - genetics Influenza A virus - physiology Laboratory animals Madin Darby Canine Kidney Cells Matrix protein Mice Molecular biology Monoclonal antibodies Monocytes Monocytes - metabolism Monocytes - virology Myeloid cells NS1 protein Nuclear transport Orthomyxoviridae Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Oseltamivir Oseltamivir - administration & dosage Oseltamivir - pharmacology Pandemics Protein Stability Protein transport Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reporter gene Tropism Vaccines Viral Matrix Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral Tropism - drug effects Virus Replication - drug effects Viruses
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