A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model
Nearly 1.3 million total joint replacement procedures are performed in the United States annually, with numbers projected to rise exponentially in the coming decades. Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause...
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| Veröffentlicht in: | PloS one 2015-03, Vol.10 (3), p.e0118696-e0118696 |
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| description | Nearly 1.3 million total joint replacement procedures are performed in the United States annually, with numbers projected to rise exponentially in the coming decades. Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause of implant failure, requiring secondary or revision procedures. Revision procedures manifest several-fold higher infection recurrence rates. Importantly, many revision surgeries, infected or not, require bone void fillers to support the host bone and provide a sufficient tissue bed for new hardware placement. Antibiotic-eluting bone void fillers (ABVF), providing both osteoconductive and antimicrobial properties, represent one approach for reducing rates of orthopedic device-related infections. Using a solvent-free, molten-cast process, a polymer-controlled antibiotic-eluting calcium carbonate hydroxyapatite (HAP) ceramic composite BVF (ABVF) was fabricated, characterized, and evaluated in vivo using a bacterial challenge in a rabbit radial defect window model. ABVF loaded with tobramycin eliminated the infectious burden in rabbits challenged with a clinically relevant strain of Staphylococcus aureus (inoculum as high as 10⁷ CFU). Histological, microbiological, and radiographic methods were used to detail the effects of ABVF on microbial challenge to host bone after 8 weeks in vivo. In contrast to the HAP/BVF controls, which provided no antibiotic protection and required euthanasia 3 weeks post-operatively, tobramycin-releasing ABVF animals showed no signs of infection (clinical, microbiological, or radiographic) when euthanized at the 8-week study endpoint. ABVF sites did exhibit fibrous encapsulation around the implant at 8 weeks. Local antibiotic release from ABVF to orthopedic sites requiring bone void fillers eliminated the periprosthetic bacterial challenge in this 8-week in vivo study, confirming previous in vitro results. |
| doi_str_mv | 10.1371/journal.pone.0118696 |
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Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause of implant failure, requiring secondary or revision procedures. Revision procedures manifest several-fold higher infection recurrence rates. Importantly, many revision surgeries, infected or not, require bone void fillers to support the host bone and provide a sufficient tissue bed for new hardware placement. Antibiotic-eluting bone void fillers (ABVF), providing both osteoconductive and antimicrobial properties, represent one approach for reducing rates of orthopedic device-related infections. Using a solvent-free, molten-cast process, a polymer-controlled antibiotic-eluting calcium carbonate hydroxyapatite (HAP) ceramic composite BVF (ABVF) was fabricated, characterized, and evaluated in vivo using a bacterial challenge in a rabbit radial defect window model. ABVF loaded with tobramycin eliminated the infectious burden in rabbits challenged with a clinically relevant strain of Staphylococcus aureus (inoculum as high as 10⁷ CFU). Histological, microbiological, and radiographic methods were used to detail the effects of ABVF on microbial challenge to host bone after 8 weeks in vivo. In contrast to the HAP/BVF controls, which provided no antibiotic protection and required euthanasia 3 weeks post-operatively, tobramycin-releasing ABVF animals showed no signs of infection (clinical, microbiological, or radiographic) when euthanized at the 8-week study endpoint. ABVF sites did exhibit fibrous encapsulation around the implant at 8 weeks. Local antibiotic release from ABVF to orthopedic sites requiring bone void fillers eliminated the periprosthetic bacterial challenge in this 8-week in vivo study, confirming previous in vitro results.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0118696</identifier><identifier>PMID: 25815727</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics ; Biocompatibility ; Biomedical materials ; Bone Substitutes - chemistry ; Bones ; Calcium ; Calcium carbonate ; Calcium Carbonate - chemistry ; Ceramics - chemistry ; Composite materials ; Defects ; Drug resistance ; Durapatite - chemistry ; Euthanasia ; Fillers ; Health aspects ; Hydroxyapatite ; Hydroxyapatites ; Hypotheses ; In vivo methods and tests ; Infection ; Infections ; Inoculum ; Joint surgery ; Microorganisms ; Osteoconduction ; Perioperative Period ; Pharmaceutical sciences ; Polymer industry ; Polymer matrix composites ; Polymers ; Polymers - chemistry ; Prosthesis-Related Infections - diagnostic imaging ; Prosthesis-Related Infections - pathology ; Prosthesis-Related Infections - prevention & control ; Rabbits ; Radiography ; Radius - diagnostic imaging ; Radius - drug effects ; Radius - pathology ; Radius - surgery ; Revisions ; Skin & tissue grafts ; Staphylococcal Infections - diagnostic imaging ; Staphylococcal Infections - pathology ; Staphylococcal Infections - prevention & control ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - physiology ; Surgical implants ; Tissue engineering ; Tobramycin ; Tobramycin - pharmacology ; Transplants & implants</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0118696-e0118696</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Brooks et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Brooks et al 2015 Brooks et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-70f4af03f71fc085d6926a2842437345637a7ba698ad0f5b2b3059b87490647d3</citedby><cites>FETCH-LOGICAL-c692t-70f4af03f71fc085d6926a2842437345637a7ba698ad0f5b2b3059b87490647d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25815727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yamamoto, Masaya</contributor><creatorcontrib>Brooks, Benjamin D</creatorcontrib><creatorcontrib>Sinclair, Kristofer D</creatorcontrib><creatorcontrib>Grainger, David W</creatorcontrib><creatorcontrib>Brooks, Amanda E</creatorcontrib><title>A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Nearly 1.3 million total joint replacement procedures are performed in the United States annually, with numbers projected to rise exponentially in the coming decades. Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause of implant failure, requiring secondary or revision procedures. Revision procedures manifest several-fold higher infection recurrence rates. Importantly, many revision surgeries, infected or not, require bone void fillers to support the host bone and provide a sufficient tissue bed for new hardware placement. Antibiotic-eluting bone void fillers (ABVF), providing both osteoconductive and antimicrobial properties, represent one approach for reducing rates of orthopedic device-related infections. Using a solvent-free, molten-cast process, a polymer-controlled antibiotic-eluting calcium carbonate hydroxyapatite (HAP) ceramic composite BVF (ABVF) was fabricated, characterized, and evaluated in vivo using a bacterial challenge in a rabbit radial defect window model. 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chemistry</subject><subject>Prosthesis-Related Infections - diagnostic imaging</subject><subject>Prosthesis-Related Infections - pathology</subject><subject>Prosthesis-Related Infections - prevention & control</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Radius - diagnostic imaging</subject><subject>Radius - drug effects</subject><subject>Radius - pathology</subject><subject>Radius - surgery</subject><subject>Revisions</subject><subject>Skin & tissue grafts</subject><subject>Staphylococcal Infections - diagnostic imaging</subject><subject>Staphylococcal Infections - pathology</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - physiology</subject><subject>Surgical implants</subject><subject>Tissue engineering</subject><subject>Tobramycin</subject><subject>Tobramycin - pharmacology</subject><subject>Transplants & implants</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQaG0F7uVLFuSbwpL6GEhEOjpVozt8a6CbDmSvTSP0LeunHXCbslFEUhC-uYfzYwmSV4yumRcsg9XbvQd2GXvOlxSxpQoxKPklBU8XYiU8scH-5PkWQhXlOZcCfE0OUlzxXKZytPkz4p4DM6XUFok0A2mNG4w1QLtOJhuQ3pnb1r0pHJt74IZkJTRIdk5U5PGWBuvGudJj964OMFgdkhM12A1GNeR3uMOu9ut6QgQD2VphrjUBiypceJI62q0z5MnDdiAL-b1LPn5-dOP86-Li8sv6_PVxaISRTosJG0yaChvJGsqqvI6ngpIVZZmXPIsF1yCLEEUCmra5GVacpoXpZJZQUUma36WvN7r9tYFPWcxaCaEZHnBVBqJ9Z6oHVzp3psW_I12YPTtgfMbDT7myKIGntOaZhwYRnHOVQEcCqxSoVgqcxm1Ps7exrLFuoq58GCPRI9vOrPVG7fTMRqhhIoC72YB765HDINuTajQWujQjft3F0JQQSP65h_04ehmagMxgFgpF_1Wk6heZSlTlIpievfyASqOGltTxR8Qa4_HBu-PDCIz4O9hA2MIev392_-zl7-O2bcH7BbBDtvgps_punAMZnuw8i4Ej819khnVU8fcZUNPHaPnjolmrw4LdG901yL8L0NqEWI</recordid><startdate>20150327</startdate><enddate>20150327</enddate><creator>Brooks, Benjamin D</creator><creator>Sinclair, Kristofer D</creator><creator>Grainger, David W</creator><creator>Brooks, Amanda E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150327</creationdate><title>A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model</title><author>Brooks, Benjamin D ; Sinclair, Kristofer D ; Grainger, David W ; Brooks, Amanda E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-70f4af03f71fc085d6926a2842437345637a7ba698ad0f5b2b3059b87490647d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brooks, Benjamin D</au><au>Sinclair, Kristofer D</au><au>Grainger, David W</au><au>Brooks, Amanda E</au><au>Yamamoto, Masaya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-27</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0118696</spage><epage>e0118696</epage><pages>e0118696-e0118696</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Nearly 1.3 million total joint replacement procedures are performed in the United States annually, with numbers projected to rise exponentially in the coming decades. Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause of implant failure, requiring secondary or revision procedures. Revision procedures manifest several-fold higher infection recurrence rates. Importantly, many revision surgeries, infected or not, require bone void fillers to support the host bone and provide a sufficient tissue bed for new hardware placement. Antibiotic-eluting bone void fillers (ABVF), providing both osteoconductive and antimicrobial properties, represent one approach for reducing rates of orthopedic device-related infections. Using a solvent-free, molten-cast process, a polymer-controlled antibiotic-eluting calcium carbonate hydroxyapatite (HAP) ceramic composite BVF (ABVF) was fabricated, characterized, and evaluated in vivo using a bacterial challenge in a rabbit radial defect window model. ABVF loaded with tobramycin eliminated the infectious burden in rabbits challenged with a clinically relevant strain of Staphylococcus aureus (inoculum as high as 10⁷ CFU). Histological, microbiological, and radiographic methods were used to detail the effects of ABVF on microbial challenge to host bone after 8 weeks in vivo. In contrast to the HAP/BVF controls, which provided no antibiotic protection and required euthanasia 3 weeks post-operatively, tobramycin-releasing ABVF animals showed no signs of infection (clinical, microbiological, or radiographic) when euthanized at the 8-week study endpoint. ABVF sites did exhibit fibrous encapsulation around the implant at 8 weeks. Local antibiotic release from ABVF to orthopedic sites requiring bone void fillers eliminated the periprosthetic bacterial challenge in this 8-week in vivo study, confirming previous in vitro results.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25815727</pmid><doi>10.1371/journal.pone.0118696</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0118696-e0118696 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_1667159182 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Biocompatibility Biomedical materials Bone Substitutes - chemistry Bones Calcium Calcium carbonate Calcium Carbonate - chemistry Ceramics - chemistry Composite materials Defects Drug resistance Durapatite - chemistry Euthanasia Fillers Health aspects Hydroxyapatite Hydroxyapatites Hypotheses In vivo methods and tests Infection Infections Inoculum Joint surgery Microorganisms Osteoconduction Perioperative Period Pharmaceutical sciences Polymer industry Polymer matrix composites Polymers Polymers - chemistry Prosthesis-Related Infections - diagnostic imaging Prosthesis-Related Infections - pathology Prosthesis-Related Infections - prevention & control Rabbits Radiography Radius - diagnostic imaging Radius - drug effects Radius - pathology Radius - surgery Revisions Skin & tissue grafts Staphylococcal Infections - diagnostic imaging Staphylococcal Infections - pathology Staphylococcal Infections - prevention & control Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Surgical implants Tissue engineering Tobramycin Tobramycin - pharmacology Transplants & implants |
| title | A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T10%3A03%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20resorbable%20antibiotic-eluting%20polymer%20composite%20bone%20void%20filler%20for%20perioperative%20infection%20prevention%20in%20a%20rabbit%20radial%20defect%20model&rft.jtitle=PloS%20one&rft.au=Brooks,%20Benjamin%20D&rft.date=2015-03-27&rft.volume=10&rft.issue=3&rft.spage=e0118696&rft.epage=e0118696&rft.pages=e0118696-e0118696&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0118696&rft_dat=%3Cgale_plos_%3EA421800697%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1667159182&rft_id=info:pmid/25815727&rft_galeid=A421800697&rft_doaj_id=oai_doaj_org_article_a350d043a1e6473389a3a9ec26812757&rfr_iscdi=true |