The differential expression of OCT4 isoforms in cervical carcinoma

OCT4 is a transcription factor involved in maintaining stem cell phenotype and pluripotential. However, it remains unclear the expression pattern and biological function of OCT4 isoforms in cervical cancer. Here, we reported that both nuclear OCT4A and cytoplasmic OCT4B were overexpressed in CC. OCT...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118033-e0118033
Hauptverfasser:	Li, Shao-Wen, Wu, Xiao-Ling, Dong, Chun-Li, Xie, Xiu-Ying, Wu, Jin-Fang, Zhang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Breast cancer Cancer Carcinogenesis CD34 antigen Cell Line, Tumor Cell Proliferation Cell self-renewal Cell Transformation, Neoplastic Cervical cancer Cervical carcinoma Cervix Development and progression Female Gelatinase A Gelatinase B Gene Expression Regulation, Neoplastic Growth factors Gynecology Human papillomavirus Humans Interleukin 6 Isoforms Medical schools Medical screening Mesenchyme Metastases Mice Neovascularization, Pathologic Obstetrics Oct-4 protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Phenotypes Pluripotency Prostate cancer Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Stem cells Transcription factors Tumorigenesis Tumors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Vascular endothelial growth factor
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