Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta

Maternal nicotine exposure has been associated with many adverse fetal and placental outcomes. Although underlying mechanisms remain elusive, recent studies have identified that augmented endoplasmic reticulum (ER) stress is linked to placental insufficiency. Moreover, ER function depends on proper...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0122295-e0122295
Hauptverfasser:	Wong, Michael K, Nicholson, Catherine J, Holloway, Alison C, Hardy, Daniel B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acids Amino Acids - metabolism Animals Apoptosis Biomarkers Birth weight Bonding Brain research Cell cycle Chemical bonds Cigarettes Deprivation Diabetic retinopathy DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug dosages Embryos Endoplasmic reticulum Endoplasmic Reticulum Stress Enzymes Exposure Female Fetuses Gene expression Gene Expression Regulation Gynecology Health risk assessment Hypoxia Hypoxia - metabolism In vivo methods and tests Kinases Maternal Exposure - adverse effects Medical research Molecular biology Nicotine Nicotine - adverse effects Obstetrics Oxidases Oxidoreductases - genetics Oxidoreductases - metabolism Oxygen Phosphorylation Physiology Placenta Placenta - metabolism Postpartum period Pregnancy Protein disulfide-isomerase Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Proteins Rats Regulatory Factor X Transcription Factors RNA RNA Splicing Signal Transduction Smoking Stress Stresses Tobacco smoke Transcription Factor CHOP - metabolism Transcription Factors - genetics Transcription Factors - metabolism Unfolded Protein Response
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