In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth

Degarelix is a gonadrotropin-releasing hormone (GnRH) receptor (GnRHR) antagonist used in patients with prostate cancer who need androgen deprivation therapy. GnRHRs have been found in extra-pituitary tissues, including prostate, which may be affected by the GnRH and GnRH analogues used in therapy....

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120670-e0120670
Hauptverfasser:	Sakai, Monica, Martinez-Arguelles, Daniel B, Patterson, Nathan H, Chaurand, Pierre, Papadopoulos, Vassilios
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Angiogenesis Apoptosis Apoptosis - drug effects Binding sites Biochemistry Biological activity Biotechnology Cancer Caspase Caspase-3 Caspases - metabolism Castration Cell adhesion Cell cycle Cell growth Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Change detection Computational Biology - methods Deprivation Fingerprints Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Ontology Genes Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Goserelin - pharmacology Growth Humans Hyperplasia Ionization Kinases Leuprolide - pharmacology Male MAP kinase Mass spectrometry Mass spectroscopy Molecular chains Molecular modelling Neurohormones Oligopeptides - pharmacology Patients Pituitary Pituitary hormones Prostate Prostate - cytology Prostate - drug effects Prostate - metabolism Prostate cancer Protein kinase Proteins Proteomics - methods Receptors Receptors, LHRH - antagonists & inhibitors Receptors, LHRH - genetics Receptors, LHRH - metabolism Rodents Scientific imaging Testosterone Therapy
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