Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response
A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response. The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500...
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| creator | Frias, Mario Rivero-Juarez, Antonio Gordon, Ana Camacho, Angela Cantisan, Sara Cuenca-Lopez, Francisca Torre-Cisneros, Julian Peña, Jose Rivero, Antonio |
| description | A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response.
The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study.
The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46.
Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors. |
| doi_str_mv | 10.1371/journal.pone.0121019 |
| format | Article |
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The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study.
The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46.
Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0121019</identifier><identifier>PMID: 25811634</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Analysis ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; CD16 antigen ; CD4 antigen ; CD56 antigen ; Cytotoxicity ; Fc receptors ; Female ; Flow Cytometry ; Health aspects ; Highly active antiretroviral therapy ; HIV ; HIV infections ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV patients ; Human immunodeficiency virus ; Humans ; Immune response ; Immune system ; Immunity ; Immunology ; Infection ; Infections ; Infectious diseases ; Killer cells ; Killer Cells, Natural - immunology ; Killer Cells, Natural - pathology ; Linear Models ; Load distribution ; Lymphocyte Count ; Maimonides (Moses ben Maimon) (1135-1204) ; Male ; Middle Aged ; Multivariate Analysis ; Natural Cytotoxicity Triggering Receptor 1 - metabolism ; Natural Cytotoxicity Triggering Receptor 3 - metabolism ; Patients ; Receptors ; Software ; Studies ; Tissue Donors ; Toxicity ; Variables ; Viral infections ; Viral Load ; Viruses</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0121019-e0121019</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Frias et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Frias et al 2015 Frias et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d08023a325eea600b51feb1d9d80a388e4abaec90cca0c41b7474c63e018d6013</citedby><cites>FETCH-LOGICAL-c692t-d08023a325eea600b51feb1d9d80a388e4abaec90cca0c41b7474c63e018d6013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374841/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374841/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25811634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sandberg, Johan K.</contributor><creatorcontrib>Frias, Mario</creatorcontrib><creatorcontrib>Rivero-Juarez, Antonio</creatorcontrib><creatorcontrib>Gordon, Ana</creatorcontrib><creatorcontrib>Camacho, Angela</creatorcontrib><creatorcontrib>Cantisan, Sara</creatorcontrib><creatorcontrib>Cuenca-Lopez, Francisca</creatorcontrib><creatorcontrib>Torre-Cisneros, Julian</creatorcontrib><creatorcontrib>Peña, Jose</creatorcontrib><creatorcontrib>Rivero, Antonio</creatorcontrib><title>Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response.
The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study.
The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46.
Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Analysis</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>CD16 antigen</subject><subject>CD4 antigen</subject><subject>CD56 antigen</subject><subject>Cytotoxicity</subject><subject>Fc receptors</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Health aspects</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Infection</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Killer cells</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - pathology</subject><subject>Linear Models</subject><subject>Load distribution</subject><subject>Lymphocyte Count</subject><subject>Maimonides (Moses ben Maimon) (1135-1204)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Natural Cytotoxicity Triggering Receptor 1 - metabolism</subject><subject>Natural Cytotoxicity Triggering Receptor 3 - metabolism</subject><subject>Patients</subject><subject>Receptors</subject><subject>Software</subject><subject>Studies</subject><subject>Tissue Donors</subject><subject>Toxicity</subject><subject>Variables</subject><subject>Viral infections</subject><subject>Viral 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of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response</title><author>Frias, Mario ; Rivero-Juarez, Antonio ; Gordon, Ana ; Camacho, Angela ; Cantisan, Sara ; Cuenca-Lopez, Francisca ; Torre-Cisneros, Julian ; Peña, Jose ; Rivero, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d08023a325eea600b51feb1d9d80a388e4abaec90cca0c41b7474c63e018d6013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Analysis</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>CD16 antigen</topic><topic>CD4 antigen</topic><topic>CD56 antigen</topic><topic>Cytotoxicity</topic><topic>Fc receptors</topic><topic>Female</topic><topic>Flow 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NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-26</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0121019</spage><epage>e0121019</epage><pages>e0121019-e0121019</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response.
The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study.
The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46.
Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25811634</pmid><doi>10.1371/journal.pone.0121019</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0121019-e0121019 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult AIDS Analysis Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active CD16 antigen CD4 antigen CD56 antigen Cytotoxicity Fc receptors Female Flow Cytometry Health aspects Highly active antiretroviral therapy HIV HIV infections HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV patients Human immunodeficiency virus Humans Immune response Immune system Immunity Immunology Infection Infections Infectious diseases Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - pathology Linear Models Load distribution Lymphocyte Count Maimonides (Moses ben Maimon) (1135-1204) Male Middle Aged Multivariate Analysis Natural Cytotoxicity Triggering Receptor 1 - metabolism Natural Cytotoxicity Triggering Receptor 3 - metabolism Patients Receptors Software Studies Tissue Donors Toxicity Variables Viral infections Viral Load Viruses |
| title | Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response |
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