Effects of malaria parasite density on blood cell parameters
Changes in blood cell parameters are already a well-known feature of malarial infections. To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphr...
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| creator | Kotepui, Manas Piwkham, Duangjai PhunPhuech, Bhukdee Phiwklam, Nuoil Chupeerach, Chaowanee Duangmano, Suwit |
| description | Changes in blood cell parameters are already a well-known feature of malarial infections. To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphra Hospital, Tak Province, Thailand between January 1st 2009 and January 1st 2012 were recruited as subjects for data collection. Blood cell parameters of 2,024 malaria-infected patients were evaluated and statistically analyzed. Neutrophil and platelet counts were significantly higher, however, RBC count was significantly lower in patients with P. falciparum infection compared to those with P. vivax infection (p |
| doi_str_mv | 10.1371/journal.pone.0121057 |
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To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphra Hospital, Tak Province, Thailand between January 1st 2009 and January 1st 2012 were recruited as subjects for data collection. Blood cell parameters of 2,024 malaria-infected patients were evaluated and statistically analyzed. Neutrophil and platelet counts were significantly higher, however, RBC count was significantly lower in patients with P. falciparum infection compared to those with P. vivax infection (p<0.0001). Leukocyte counts were also significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia. In terms of differential leukocyte count, neutrophil count was significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia (p<0.0001). On the other hand, both lymphocyte and monocyte counts were significantly lower in patients with high parasitemia (p<0.0001). RBC count and Hb concentration, as well as platelet count were also significantly reduced (p<0.05) and (p<0.0001), respectively. To summarize, patients infected with different malaria parasites exhibited important distinctive hematological parameters, with neutrophil and eosinophil counts being the two hematological parameters most affected. In addition, patients infected with different malarial densities also exhibited important changes in leukocyte count, platelet count and hemoglobin concentration during the infection. These findings offer the opportunity to recognize and diagnose malaria related anemia, help support the treatment thereof, as well as relieve symptoms of severe malaria in endemic regions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0121057</identifier><identifier>PMID: 25807235</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anemia ; Blood ; Blood Cells - parasitology ; Blood platelets ; Child ; Child, Preschool ; Comparative analysis ; Data collection ; Eosinophils - parasitology ; Erythrocytes ; Female ; Health sciences ; Hematology ; Hemoglobin ; Hemoglobins ; Hospitals ; Humans ; Infant ; Infection ; Infections ; Laboratories ; Leukocyte Count - methods ; Leukocytes ; Leukocytes (eosinophilic) ; Malaria ; Malaria, Falciparum - blood ; Malaria, Falciparum - parasitology ; Malaria, Vivax - blood ; Malaria, Vivax - parasitology ; Male ; Medical technology ; Middle Aged ; Monocytes ; Neutrophils - parasitology ; Oil fields ; Parameters ; Parasitemia ; Parasitemia - blood ; Parasitemia - parasitology ; Parasites ; Patients ; Plasmodium falciparum ; Plasmodium falciparum - physiology ; Plasmodium vivax - physiology ; Platelet Count - methods ; Platelets ; Public health ; Studies ; Thailand ; Vector-borne diseases ; Young Adult</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0121057-e0121057</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kotepui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kotepui et al 2015 Kotepui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9e0487086a4fa12e3671048ed42246c65eb6782d1efcc236c3cd2bbe0ce7135b3</citedby><cites>FETCH-LOGICAL-c692t-9e0487086a4fa12e3671048ed42246c65eb6782d1efcc236c3cd2bbe0ce7135b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373695/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373695/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25807235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Przyborski, Jude Marek</contributor><creatorcontrib>Kotepui, Manas</creatorcontrib><creatorcontrib>Piwkham, Duangjai</creatorcontrib><creatorcontrib>PhunPhuech, Bhukdee</creatorcontrib><creatorcontrib>Phiwklam, Nuoil</creatorcontrib><creatorcontrib>Chupeerach, Chaowanee</creatorcontrib><creatorcontrib>Duangmano, Suwit</creatorcontrib><title>Effects of malaria parasite density on blood cell parameters</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Changes in blood cell parameters are already a well-known feature of malarial infections. To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphra Hospital, Tak Province, Thailand between January 1st 2009 and January 1st 2012 were recruited as subjects for data collection. Blood cell parameters of 2,024 malaria-infected patients were evaluated and statistically analyzed. Neutrophil and platelet counts were significantly higher, however, RBC count was significantly lower in patients with P. falciparum infection compared to those with P. vivax infection (p<0.0001). Leukocyte counts were also significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia. In terms of differential leukocyte count, neutrophil count was significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia (p<0.0001). On the other hand, both lymphocyte and monocyte counts were significantly lower in patients with high parasitemia (p<0.0001). RBC count and Hb concentration, as well as platelet count were also significantly reduced (p<0.05) and (p<0.0001), respectively. To summarize, patients infected with different malaria parasites exhibited important distinctive hematological parameters, with neutrophil and eosinophil counts being the two hematological parameters most affected. In addition, patients infected with different malarial densities also exhibited important changes in leukocyte count, platelet count and hemoglobin concentration during the infection. These findings offer the opportunity to recognize and diagnose malaria related anemia, help support the treatment thereof, as well as relieve symptoms of severe malaria in endemic regions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Blood</subject><subject>Blood Cells - parasitology</subject><subject>Blood platelets</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comparative analysis</subject><subject>Data collection</subject><subject>Eosinophils - parasitology</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Health sciences</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infection</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Leukocyte Count - methods</subject><subject>Leukocytes</subject><subject>Leukocytes (eosinophilic)</subject><subject>Malaria</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malaria, Vivax - blood</subject><subject>Malaria, Vivax - parasitology</subject><subject>Male</subject><subject>Medical technology</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Neutrophils - parasitology</subject><subject>Oil fields</subject><subject>Parameters</subject><subject>Parasitemia</subject><subject>Parasitemia - blood</subject><subject>Parasitemia - parasitology</subject><subject>Parasites</subject><subject>Patients</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - physiology</subject><subject>Plasmodium vivax - physiology</subject><subject>Platelet Count - methods</subject><subject>Platelets</subject><subject>Public health</subject><subject>Studies</subject><subject>Thailand</subject><subject>Vector-borne diseases</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbF39B6IDgujFrvmaZBdEKKXqQqHg123IJGd2UzKTbZIR--_N7E7LjvRC5iLDyXPe5Lx5i-IlRgtMBf5w7fvQKbfY-Q4WCBOMKvGoOMUrSuacIPr46P-keBbjNUIVXXL-tDgh1RIJQqvT4uNF04BOsfRN2SqnglXlTgUVbYLSQJfX29J3Ze28N6UG5_bbLSQI8XnxpFEuwotxnRU_P1_8OP86v7z6sj4_u5xrviJpvgLElgItuWKNwgQoFzhXwDBCGNe8gpqLJTEYGq0J5ZpqQ-oakAaBaVXTWfH6oLtzPspx8Cgx51wwwQjLxPpAGK-u5S7YVoVb6ZWV-4IPG6lCstqBXGWrtKqhYQwzjnmtoQJDSa4ZBQZlrU_jaX3dgtHQpaDcRHS609mt3PjfklFB-arKAu9GgeBveohJtjYO1qkOfL-_t6AVwXS495t_0IenG6mNygPYrvH5XD2IyrPsYU7D8JqzYvEAlT8DrdU5JY3N9UnD-0lDZhL8SRvVxyjX37_9P3v1a8q-PWK3oFzaRu_6ZH0XpyA7gDr4GAM09yZjJIeQ37khh5DLMeS57dXxA9033aWa_gWE-fXu</recordid><startdate>20150325</startdate><enddate>20150325</enddate><creator>Kotepui, Manas</creator><creator>Piwkham, Duangjai</creator><creator>PhunPhuech, Bhukdee</creator><creator>Phiwklam, Nuoil</creator><creator>Chupeerach, Chaowanee</creator><creator>Duangmano, Suwit</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150325</creationdate><title>Effects of malaria parasite density on blood cell parameters</title><author>Kotepui, Manas ; Piwkham, Duangjai ; PhunPhuech, Bhukdee ; Phiwklam, Nuoil ; Chupeerach, Chaowanee ; Duangmano, Suwit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9e0487086a4fa12e3671048ed42246c65eb6782d1efcc236c3cd2bbe0ce7135b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Blood</topic><topic>Blood Cells - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotepui, Manas</au><au>Piwkham, Duangjai</au><au>PhunPhuech, Bhukdee</au><au>Phiwklam, Nuoil</au><au>Chupeerach, Chaowanee</au><au>Duangmano, Suwit</au><au>Przyborski, Jude Marek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of malaria parasite density on blood cell parameters</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-25</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0121057</spage><epage>e0121057</epage><pages>e0121057-e0121057</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Changes in blood cell parameters are already a well-known feature of malarial infections. To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphra Hospital, Tak Province, Thailand between January 1st 2009 and January 1st 2012 were recruited as subjects for data collection. Blood cell parameters of 2,024 malaria-infected patients were evaluated and statistically analyzed. Neutrophil and platelet counts were significantly higher, however, RBC count was significantly lower in patients with P. falciparum infection compared to those with P. vivax infection (p<0.0001). Leukocyte counts were also significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia. In terms of differential leukocyte count, neutrophil count was significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia (p<0.0001). On the other hand, both lymphocyte and monocyte counts were significantly lower in patients with high parasitemia (p<0.0001). RBC count and Hb concentration, as well as platelet count were also significantly reduced (p<0.05) and (p<0.0001), respectively. To summarize, patients infected with different malaria parasites exhibited important distinctive hematological parameters, with neutrophil and eosinophil counts being the two hematological parameters most affected. In addition, patients infected with different malarial densities also exhibited important changes in leukocyte count, platelet count and hemoglobin concentration during the infection. These findings offer the opportunity to recognize and diagnose malaria related anemia, help support the treatment thereof, as well as relieve symptoms of severe malaria in endemic regions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25807235</pmid><doi>10.1371/journal.pone.0121057</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0121057-e0121057 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1666747424 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Aged, 80 and over Anemia Blood Blood Cells - parasitology Blood platelets Child Child, Preschool Comparative analysis Data collection Eosinophils - parasitology Erythrocytes Female Health sciences Hematology Hemoglobin Hemoglobins Hospitals Humans Infant Infection Infections Laboratories Leukocyte Count - methods Leukocytes Leukocytes (eosinophilic) Malaria Malaria, Falciparum - blood Malaria, Falciparum - parasitology Malaria, Vivax - blood Malaria, Vivax - parasitology Male Medical technology Middle Aged Monocytes Neutrophils - parasitology Oil fields Parameters Parasitemia Parasitemia - blood Parasitemia - parasitology Parasites Patients Plasmodium falciparum Plasmodium falciparum - physiology Plasmodium vivax - physiology Platelet Count - methods Platelets Public health Studies Thailand Vector-borne diseases Young Adult |
| title | Effects of malaria parasite density on blood cell parameters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T23%3A27%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20malaria%20parasite%20density%20on%20blood%20cell%20parameters&rft.jtitle=PloS%20one&rft.au=Kotepui,%20Manas&rft.date=2015-03-25&rft.volume=10&rft.issue=3&rft.spage=e0121057&rft.epage=e0121057&rft.pages=e0121057-e0121057&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0121057&rft_dat=%3Cgale_plos_%3EA422371072%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1666747424&rft_id=info:pmid/25807235&rft_galeid=A422371072&rft_doaj_id=oai_doaj_org_article_9121cabef4414616bce5ed32cabdaed0&rfr_iscdi=true |