Sex-specific effects of cardiovascular risk factors on endothelium-dependent dilation and endothelin activity in middle-aged women and men

Healthy middle-aged postmenopausal women have higher endothelium-dependent dilation and lower vasoconstrictor activity of endothelin-1 than men. Whether these sex-specific differences extend to patients with cardiovascular risk factors has not been investigated. The current study aimed to determine...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121810-e0121810
Hauptverfasser:	Brar, Vijaywant, Gill, Sartaj, Cardillo, Carmine, Tesauro, Manfredi, Panza, Julio A, Campia, Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Atherosclerosis Blood flow Cardiac patients Cardiology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Diabetes Dilation Drugs Endocrinology Endothelin Endothelin 1 Endothelin Receptor Antagonists - pharmacology Endothelin-1 - metabolism Endothelins Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Family medical history FDA approval Female Forearm Forearm - physiopathology Gender differences Health risk assessment Health risks Hospitals Humans Hypertension Infusions, Intra-Arterial - methods Insulin Internal medicine Laboratories Male Men Metabolism Middle age Middle Aged Nitroprusside Nitroprusside - pharmacology Patients Peptides, Cyclic - pharmacology Physiology Plethysmography Post-menopause Postmenopausal women Regional Blood Flow - drug effects Risk analysis Risk Factors Sex Sex Characteristics Sodium Sodium nitroprusside Strain gauges Studies Vasodilation Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Womens health
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