Decoding diffusivity in multiple sclerosis: analysis of optic radiation lesional and non-lesional white matter

Diffusion tensor imaging (DTI) has been suggested as a new promising tool in MS that may provide greater pathological specificity than conventional MRI, helping, therefore, to elucidate disease pathogenesis and monitor therapeutic efficacy. However, the pathological substrates that underpin alterati...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0122114-e0122114
Hauptverfasser:	Klistorner, Alexander, Vootakuru, Nikitha, Wang, Chenyu, Yiannikas, Con, Graham, Stuart L, Parratt, John, Garrick, Raymond, Levin, Netta, Masters, Lynette, Lagopoulos, Jim, Barnett, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Axons Brain Brain research Case-Control Studies Decoding Degeneration Demyelination Diffusion Tensor Imaging Diffusivity Female Fibers Health aspects Hospitals Humans Image Interpretation, Computer-Assisted Lesions Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - complications Multiple Sclerosis, Relapsing-Remitting - pathology Myelin Nerve Fibers, Myelinated - pathology Neurodegeneration Neuroimaging NMR Nuclear magnetic resonance Optic Neuritis - etiology Optic Neuritis - pathology Pathogenesis Pathology Radiation Radiation (Physics) Radiation damage Radiography Studies Substantia alba Substrates White Matter - diagnostic imaging White Matter - pathology
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