Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis

PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in prostate cancer (PCa). PCa is a heterogeneous dise...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121318-e0121318
Hauptverfasser:	Xiao, Guang-Qian, Unger, Pamela, Yang, Qi, Kinoshita, Yayoi, Singh, Kyra, McMahon, Loralee, Nastiuk, Kent, Sha, Kai, Krolewski, John, Burstein, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Aggressive behavior Androgens Antigens Apoptosis Basal cells Bioindicators Biomarkers Biopsy Cancer Cancer metastasis Cancer surgery Cell cycle Cell growth Chromosomes Development and progression Disease Progression Genes Genomics Humans Immunohistochemistry Kruppel-Like Transcription Factors - metabolism Leukemia Lymph Node Excision Lymph nodes Lymphatic system Male Metastases Metastasis Molecular chains Neoplasm Grading Neoplasm Invasiveness - pathology Neoplasm Metastasis - pathology Pathology Promyelocytic Leukemia Zinc Finger Protein Prostate cancer Prostatectomy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Proteins Review boards Spermatogenesis Transcription Tumor cell lines Tumorigenesis Tumors Urological surgery
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