Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues

Several clinical trials in oncology have reported increased mortality or disease progression associated with erythropoiesis-stimulating agents. One hypothesis proposes that erythropoiesis-stimulating agents directly stimulate tumor proliferation and/or survival through cell-surface receptors. To tes...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0122149-e0122149
Hauptverfasser:	Patterson, Scott D, Rossi, John M, Paweletz, Katherine L, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Analysis Anemia Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology c-Met protein Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cardiology Cell culture Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell surface Cell survival Cell Survival - drug effects Chemotherapy Clinical trials Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Epidermal Growth Factor - pharmacology Epidermal growth factor receptors Epoetin Alfa - pharmacology Erythropoiesis Erythropoietin Extracellular Signal-Regulated MAP Kinases - metabolism Female Flow cytometry Gene expression Glycoproteins Growth factors Head Head and neck Health aspects Heart attacks Hepatocyte Growth Factor - pharmacology HT29 Cells Humans Hypotheses Insulin-like growth factor I Insulin-Like Growth Factor I - pharmacology Kidneys Lung cancer Lungs Male Medical research Metastases Mortality Oncology Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Phosphorylation - drug effects Proteins Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-met - metabolism R&D Receptor, Epidermal Growth Factor - metabolism Receptor, IGF Type 1 - metabolism Receptors Receptors, Erythropoietin - metabolism Recombinant erythropoietin Research & development Signal Transduction - drug effects Studies Survival Tissues Transforming growth factors Transplants & implants Tumor cells Tumors
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