Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions

Whole genome analysis in large samples from a single population is needed to provide adequate power to assess relative strengths of natural selection across different functional components of the genome. In this study, we analyzed next-generation sequencing data from 962 European Americans, and foun...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121644-e0121644
Hauptverfasser:	Yu, Fuli, Lu, Jian, Liu, Xiaoming, Gazave, Elodie, Chang, Diana, Raj, Srilakshmi, Hunter-Zinck, Haley, Blekhman, Ran, Arbiza, Leonardo, Van Hout, Cris, Morrison, Alanna, Johnson, Andrew D, Bis, Joshua, Cupples, L Adrienne, Psaty, Bruce M, Muzny, Donna, Yu, Jin, Gibbs, Richard A, Keinan, Alon, Clark, Andrew G, Boerwinkle, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Automation Binding sites Biosynthesis Comparative analysis Data processing DNA, Intergenic Enhancers Enrichment Epidemiology Gene sequencing Genetic aspects Genetic Loci Genetics Genomes Genomic analysis Genomics Health services Heart Humans Life sciences Loci Mammals Medical research Medicine Metagenomics MicroRNA MicroRNAs Minority & ethnic groups miRNA Molecular biology Natural selection Open Reading Frames Polymorphism, Single Nucleotide Positive selection Statistical analysis Statistical methods Studies Yu, Jian
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