Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen) and a toxoid fusion of heat-stable toxin (STa) and heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC) retain broad anti-CFA and antitoxin antigenicity

Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC) strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunol...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0121623
Hauptverfasser:	Ruan, Xiaosai, Sack, David A, Zhang, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Antibodies Antibodies, Bacterial - blood Antigenic determinants Antigenicity Antigens Antigens, Bacterial - immunology Artificial Gene Fusion - methods Bacteria Bacterial Toxins - genetics Bacterial Toxins - toxicity Bacterial Vaccines Cholera Colonization Colonization factor Consortia Developing countries Diarrhea Drug dosages E coli Enterotoxigenic Escherichia coli - genetics Enterotoxigenic Escherichia coli - metabolism Enterotoxins Enterotoxins - genetics Enterotoxins - toxicity Epitopes Escherichia coli Escherichia coli Proteins - genetics Escherichia coli Proteins - toxicity Fimbriae Proteins - genetics Fimbriae Proteins - immunology Genetic research Health aspects Heat Immunity Immunization Immunogenicity Immunoglobulins Immunology Laboratory animals LDCs Mice Neutralization Neutralization Tests Strains (organisms) Suidae Thermal stability Toxins Vaccine development Vaccines Veterinary colleges Veterinary medicine Wildlife conservation
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