Proteomic analysis of INS-1 rat insulinoma cells: ER stress effects and the protective role of exenatide, a GLP-1 receptor agonist

Beta cell death caused by endoplasmic reticulum (ER) stress is a key factor aggravating type 2 diabetes. Exenatide, a glucagon-like peptide (GLP)-1 receptor agonist, prevents beta cell death induced by thapsigargin, a selective inhibitor of ER calcium storage. Here, we report on our proteomic studie...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120536-e0120536
Hauptverfasser:	Kim, Mi-Kyung, Cho, Jin-Hwan, Lee, Jae-Jin, Son, Moon-Ho, Lee, Kong-Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - metabolism Animals Antidiabetics Apoptosis Beta cells Calcium Cell culture Cell death Cell Death - drug effects Cell Line Comparative analysis Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects GLP-1 receptor agonists Glucagon Glucagon-Like Peptide-1 Receptor - agonists Glucose Heat shock proteins Hypoglycemic agents Insulin Insulinoma Insulinoma - metabolism Isoforms Kinases Mass spectrometry Mortality Neuroendocrine tumors Oligopeptidase Pancreatic Neoplasms - metabolism Peptides Peptides - pharmacology Pharmaceutical sciences Pharmacy Phosphorylation Prevention Protein folding Protein Interaction Maps Protein Processing, Post-Translational - drug effects Proteins Proteome Proteomics Rats Rodents Scientific imaging Stress Stresses Thapsigargin Thapsigargin - pharmacology Thimet oligopeptidase Type 2 diabetes Venoms - pharmacology
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