Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils

Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in which they are highly susceptible to infectious diseases. This study identified and analyzed the functional role of the FFAR1 receptor in bov...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119715-e0119715
Hauptverfasser:	Manosalva, Carolina, Mena, Jaqueline, Velasquez, Zahady, Colenso, Charlotte K, Brauchi, Sebastian, Burgos, Rafael A, Hidalgo, Maria A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis Animals Breast cancer Calcium Calcium (intracellular) Calcium - analysis Calcium - metabolism Calcium mobilization Cattle Chain mobility Chains CHO Cells Cloning Cloning, Molecular Cricetinae Cricetulus Estrenes - pharmacology Fatty acids G protein-coupled receptors Homology Humans Infectious diseases Insulin Intracellular Ion Transport - drug effects Kinases Laboratories Leukocytes (neutrophilic) Ligands Linoleic acid Linoleic Acid - metabolism Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Metalloproteinase Methylamines - pharmacology Molecular Sequence Data Monounsaturated fatty acids Neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Oleic acid Oleic Acid - metabolism Oxygen Parturition Pharmacology Phospholipase Phospholipase C Physiology Propionates - pharmacology Propionic acid Protein kinase C Proteins Pyrrolidinones - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics Rodents Science Sequence Alignment Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism
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