A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China
We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass. A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients...
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| Veröffentlicht in: | PloS one 2015-03, Vol.10 (3), p.e0121944-e0121944 |
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| creator | Tan, Yinuo Fu, Jianfei Li, Xiaofen Yang, Jiao Jiang, Mengjie Ding, Kefeng Xu, Jinghong Li, Jun Yuan, Ying |
| description | We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.
A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).
Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).
Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention. |
| doi_str_mv | 10.1371/journal.pone.0121944 |
| format | Article |
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A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).
Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).
Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0121944</identifier><identifier>PMID: 25789685</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Cancer ; Cancer research ; Carcinoma, Signet Ring Cell - diagnosis ; Carcinoma, Signet Ring Cell - metabolism ; Carcinoma, Signet Ring Cell - pathology ; Cell survival ; Chemotherapy ; China ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Disease prevention ; Female ; Gastroenterology ; Health hazards ; Histology ; Hospitals ; Humans ; Laboratories ; Male ; Medical prognosis ; Medicine ; Metastasis ; Middle Aged ; Molecular biology ; Mucin ; Mucins - metabolism ; Multivariate analysis ; Oncology ; Ostomy ; Pathology ; Patients ; Prognosis ; Recurrence ; Retrospective Studies ; Studies ; Survival ; Survival Analysis ; Tumors ; Young Adult</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0121944-e0121944</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Tan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Tan et al 2015 Tan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2f78d654cc397b561a0d28796c53f61abd46e9c171a1299b96ec779bff4d39b33</citedby><cites>FETCH-LOGICAL-c692t-2f78d654cc397b561a0d28796c53f61abd46e9c171a1299b96ec779bff4d39b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366148/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366148/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25789685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Katoh, Masaru</contributor><creatorcontrib>Tan, Yinuo</creatorcontrib><creatorcontrib>Fu, Jianfei</creatorcontrib><creatorcontrib>Li, Xiaofen</creatorcontrib><creatorcontrib>Yang, Jiao</creatorcontrib><creatorcontrib>Jiang, Mengjie</creatorcontrib><creatorcontrib>Ding, Kefeng</creatorcontrib><creatorcontrib>Xu, Jinghong</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Yuan, Ying</creatorcontrib><title>A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.
A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).
Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).
Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.]]></description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Carcinoma, Signet Ring Cell - diagnosis</subject><subject>Carcinoma, Signet Ring Cell - metabolism</subject><subject>Carcinoma, Signet Ring Cell - pathology</subject><subject>Cell survival</subject><subject>Chemotherapy</subject><subject>China</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Health hazards</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular biology</subject><subject>Mucin</subject><subject>Mucins - metabolism</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Ostomy</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v2yAUhq1p09p1-wfThjRtai-cgbHBTNOkKNpHpEqV9nWLAGOHygEXcLf8if3m4SatkqkXExfG8LzvgcM5WfYcwRnCFL29dKO3op8NzuoZRAViZfkgO0YMFzkpIH64Nz_KnoRwCWGFa0IeZ0dFRWtG6uo4-zMHa2OdB6fvK_j6DATTWR1zb2wHlO57oNx6imAjECE4ZUTUDfhl4goMLskG7zrrggnA2MT2zmsVRZIJq3TaFtEkbXgHBChIvtHCA6-jd2FInLnWIMSx2UzixcpY8TR71Io-6Ge770n249PH74sv-fnF5-Vifp4rwoqYFy2tG1KVSmFGZUWQgE1RU0ZUhdv0J5uSaKYQRQIVjElGtKKUybYtG8wkxifZy63v0LvAd6kMHBFS0rrEBCViuSUaJy754M1a-A13wvCbBec7Lnw0qtdcIqlgJRGpYF1qJGtRtbqBUApJqWQieX3YRRvlWjcqZcSL_sD0cMeaFe_cNU8nIaisk8HpzsC7q1GHyNcmTM8jrHbjzbkrhGpMYUJf_YPef7sd1Yl0AWNbl-KqyZTPywLXVc3oRM3uodJo9NqoVBWtSesHgrMDQWKi_h07MYbAl9--_j978fOQfbPHrrTo4yq4fozG2XAIlltQpRILXrd3SUaQT21zmw0-FTXftU2Svdh_oDvRbZ_gvxnqE1o</recordid><startdate>20150319</startdate><enddate>20150319</enddate><creator>Tan, Yinuo</creator><creator>Fu, Jianfei</creator><creator>Li, Xiaofen</creator><creator>Yang, Jiao</creator><creator>Jiang, Mengjie</creator><creator>Ding, Kefeng</creator><creator>Xu, Jinghong</creator><creator>Li, Jun</creator><creator>Yuan, Ying</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150319</creationdate><title>A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China</title><author>Tan, Yinuo ; Fu, Jianfei ; Li, Xiaofen ; Yang, Jiao ; Jiang, Mengjie ; Ding, Kefeng ; Xu, Jinghong ; Li, Jun ; Yuan, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2f78d654cc397b561a0d28796c53f61abd46e9c171a1299b96ec779bff4d39b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Yinuo</au><au>Fu, Jianfei</au><au>Li, Xiaofen</au><au>Yang, Jiao</au><au>Jiang, Mengjie</au><au>Ding, Kefeng</au><au>Xu, Jinghong</au><au>Li, Jun</au><au>Yuan, Ying</au><au>Katoh, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-19</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0121944</spage><epage>e0121944</epage><pages>e0121944-e0121944</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.
A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).
Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).
Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25789685</pmid><doi>10.1371/journal.pone.0121944</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0121944-e0121944 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1664784361 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - pathology Adolescent Adult Aged Aged, 80 and over Analysis Cancer Cancer research Carcinoma, Signet Ring Cell - diagnosis Carcinoma, Signet Ring Cell - metabolism Carcinoma, Signet Ring Cell - pathology Cell survival Chemotherapy China Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease prevention Female Gastroenterology Health hazards Histology Hospitals Humans Laboratories Male Medical prognosis Medicine Metastasis Middle Aged Molecular biology Mucin Mucins - metabolism Multivariate analysis Oncology Ostomy Pathology Patients Prognosis Recurrence Retrospective Studies Studies Survival Survival Analysis Tumors Young Adult |
| title | A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China |
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