Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis

Recent evidence has shown that eosinophils play an important role in metabolic homeostasis through Th2 cytokine production. GPR120 (FFA4) is a G protein-coupled receptor (GPCR) for long-chain fatty acids that functions as a regulator of physiological energy metabolism. In the present study, we aimed...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120386-e0120386
Hauptverfasser:	Konno, Yasunori, Ueki, Shigeharu, Takeda, Masahide, Kobayashi, Yoshiki, Tamaki, Mami, Moritoki, Yuki, Oyamada, Hajime, Itoga, Masamichi, Kayaba, Hiroyuki, Omokawa, Ayumi, Hirokawa, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Allergies Analysis Apoptosis Apoptosis - drug effects Caspase Caspase 3 - metabolism Caspase-3 Cell activation Cell surface Chemotactic response Cytokines Degranulation Down-regulation Energy metabolism Enzyme-linked immunosorbent assay Eosinophils Eosinophils - drug effects Eosinophils - metabolism Eosinophils - physiology fas Receptor - metabolism Fatty acids Functional analysis G protein-coupled receptors Homeostasis Homeostasis - drug effects Humans Immune system Insulin resistance Interleukin 4 Interleukin-4 - metabolism Internal medicine Internalization Kinases Laboratories Leukocytes (eosinophilic) Lymphocytes T Medicine Membrane proteins Metabolism Methylamines - pharmacology mRNA Obesity Physiology Propionates - pharmacology Protein Kinase Inhibitors - pharmacology Proteins Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA Rodents Stimulation University graduates
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