A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human
Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study,...
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| creator | Kilic, Ulkan Gok, Ozlem Erenberk, Ufuk Dundaroz, Mehmet Rusen Torun, Emel Kucukardali, Yasar Elibol-Can, Birsen Uysal, Omer Dundar, Tolga |
| description | Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene. |
| doi_str_mv | 10.1371/journal.pone.0117954 |
| format | Article |
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Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117954</identifier><identifier>PMID: 25785999</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Aging ; Analysis ; Apoptosis ; Aryldialkylphosphatase - biosynthesis ; Aryldialkylphosphatase - genetics ; Biology ; Cardiovascular disease ; Child ; Child, Preschool ; Children ; Cholesterol ; Coronary vessels ; Diabetes ; Enzymes ; Epigenetics ; Female ; Gene expression ; Gene Expression Regulation, Enzymologic - physiology ; Genes ; Genetic aspects ; Genetic diversity ; Genetic polymorphisms ; Genotypes ; Geriatrics ; Heart attacks ; Humans ; Life span ; Longevity ; Longevity - physiology ; Male ; Medicine ; Metabolism ; Middle Aged ; Mortality ; Nitric Oxide Synthase Type III - biosynthesis ; Nitric Oxide Synthase Type III - genetics ; Older people ; Oxidative stress ; Oxidative Stress - physiology ; Pediatrics ; Phenotypic variations ; Polymorphism, Single Nucleotide ; Population studies ; Proteins ; Research methodology ; Single-nucleotide polymorphism ; SIRT1 protein ; Sirtuin 1 - biosynthesis ; Sirtuin 1 - genetics ; Sirtuins ; Studies</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0117954-e0117954</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kilic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kilic et al 2015 Kilic et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f9e075251375f9e4543154b405d78a645a35ec08af7315a3f54cfcd307515c5b3</citedby><cites>FETCH-LOGICAL-c692t-f9e075251375f9e4543154b405d78a645a35ec08af7315a3f54cfcd307515c5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365019/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25785999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alway, Stephen E</contributor><creatorcontrib>Kilic, Ulkan</creatorcontrib><creatorcontrib>Gok, Ozlem</creatorcontrib><creatorcontrib>Erenberk, Ufuk</creatorcontrib><creatorcontrib>Dundaroz, Mehmet Rusen</creatorcontrib><creatorcontrib>Torun, Emel</creatorcontrib><creatorcontrib>Kucukardali, Yasar</creatorcontrib><creatorcontrib>Elibol-Can, Birsen</creatorcontrib><creatorcontrib>Uysal, Omer</creatorcontrib><creatorcontrib>Dundar, Tolga</creatorcontrib><title>A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Analysis</subject><subject>Apoptosis</subject><subject>Aryldialkylphosphatase - biosynthesis</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Biology</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic polymorphisms</subject><subject>Genotypes</subject><subject>Geriatrics</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Life span</subject><subject>Longevity</subject><subject>Longevity - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nitric Oxide Synthase Type III - biosynthesis</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Older people</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Pediatrics</subject><subject>Phenotypic variations</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Proteins</subject><subject>Research methodology</subject><subject>Single-nucleotide polymorphism</subject><subject>SIRT1 protein</subject><subject>Sirtuin 1 - biosynthesis</subject><subject>Sirtuin 1 - genetics</subject><subject>Sirtuins</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk81u1DAQxyMEoqXwBggiISE47BLHH0k4IFUVHytVqtQWrtasM8m6eO2t7ay2D8E7423Tahf1gHzwZOb3n4nHnix7TYopoRX5dOUGb8FMV87itCCkajh7kh2ShpYTURb06Y59kL0I4aooOK2FeJ4dlLyqedM0h9mf49zjEvxvmBvMoceJRwMR21xb5RECJiO_mJ1fknzlXcT0hZuVxxC0s0kA2oaYu41uIeo15iFuY1sRmha9ufk8qnu0mK_Ba7Ax5GDb3Djb41rHmy29GJZgX2bPOjABX437Ufbz29fLkx-T07Pvs5Pj04kSTRknXYNFxUue-sCTzTijhLM5K3hb1SAYB8pRFTV0VQoA7ThTnWppEhGu-JweZW_v8q6MC3LsZJBECMZEUVVVImZ3ROvgSq68Tj26kQ60vHU430vwUSuDsilr0XYEaqwYm6u2KRQKBaKq2-S4rfZlrDbMl9gqtNGD2Uu6H7F6IXu3lowKXqRLPMo-jAm8ux4wRLnUQaExYNENt__NCWk4rxP67h_08dONVA_pANp2LtVV26TymJW04aSkIlHTR6i0WlxqlZ5dp5N_T_BxT5CYiJvYwxCCnF2c_z979muffb_DLhBMXARnhpieYNgH2R2ovAvBY_fQZFLI7dTcd0Nup0aOU5Nkb3Yv6EF0Pyb0L-N_EpQ</recordid><startdate>20150318</startdate><enddate>20150318</enddate><creator>Kilic, Ulkan</creator><creator>Gok, Ozlem</creator><creator>Erenberk, Ufuk</creator><creator>Dundaroz, Mehmet Rusen</creator><creator>Torun, Emel</creator><creator>Kucukardali, Yasar</creator><creator>Elibol-Can, Birsen</creator><creator>Uysal, Omer</creator><creator>Dundar, Tolga</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150318</creationdate><title>A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human</title><author>Kilic, Ulkan ; Gok, Ozlem ; Erenberk, Ufuk ; Dundaroz, Mehmet Rusen ; Torun, Emel ; Kucukardali, Yasar ; Elibol-Can, Birsen ; Uysal, Omer ; Dundar, Tolga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f9e075251375f9e4543154b405d78a645a35ec08af7315a3f54cfcd307515c5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Analysis</topic><topic>Apoptosis</topic><topic>Aryldialkylphosphatase - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilic, Ulkan</au><au>Gok, Ozlem</au><au>Erenberk, Ufuk</au><au>Dundaroz, Mehmet Rusen</au><au>Torun, Emel</au><au>Kucukardali, Yasar</au><au>Elibol-Can, Birsen</au><au>Uysal, Omer</au><au>Dundar, Tolga</au><au>Alway, Stephen E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-18</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0117954</spage><epage>e0117954</epage><pages>e0117954-e0117954</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25785999</pmid><doi>10.1371/journal.pone.0117954</doi><tpages>e0117954</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1664460777 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Age Aged Aged, 80 and over Aging Analysis Apoptosis Aryldialkylphosphatase - biosynthesis Aryldialkylphosphatase - genetics Biology Cardiovascular disease Child Child, Preschool Children Cholesterol Coronary vessels Diabetes Enzymes Epigenetics Female Gene expression Gene Expression Regulation, Enzymologic - physiology Genes Genetic aspects Genetic diversity Genetic polymorphisms Genotypes Geriatrics Heart attacks Humans Life span Longevity Longevity - physiology Male Medicine Metabolism Middle Aged Mortality Nitric Oxide Synthase Type III - biosynthesis Nitric Oxide Synthase Type III - genetics Older people Oxidative stress Oxidative Stress - physiology Pediatrics Phenotypic variations Polymorphism, Single Nucleotide Population studies Proteins Research methodology Single-nucleotide polymorphism SIRT1 protein Sirtuin 1 - biosynthesis Sirtuin 1 - genetics Sirtuins Studies |
| title | A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T07%3A34%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20remarkable%20age-related%20increase%20in%20SIRT1%20protein%20expression%20against%20oxidative%20stress%20in%20elderly:%20SIRT1%20gene%20variants%20and%20longevity%20in%20human&rft.jtitle=PloS%20one&rft.au=Kilic,%20Ulkan&rft.date=2015-03-18&rft.volume=10&rft.issue=3&rft.spage=e0117954&rft.epage=e0117954&rft.pages=e0117954-e0117954&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117954&rft_dat=%3Cgale_plos_%3EA423951236%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1664460777&rft_id=info:pmid/25785999&rft_galeid=A423951236&rft_doaj_id=oai_doaj_org_article_9286df1a8e744bcd90ce6ca678d7445b&rfr_iscdi=true |