A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment
Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could...
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| creator | Tomioka, Hiroi Yamagata, Bun Kawasaki, Shingo Pu, Shenghong Iwanami, Akira Hirano, Jinichi Nakagome, Kazuyuki Mimura, Masaru |
| description | Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could be a neural predictor of treatment response. Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression. |
| doi_str_mv | 10.1371/journal.pone.0120828 |
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Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0120828</identifier><identifier>PMID: 25786240</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Antidepressants ; Antidepressive Agents - therapeutic use ; Bioindicators ; Biomarkers ; Biomarkers - blood ; Bipolar disorder ; Brain Mapping ; Case-Control Studies ; Cognitive ability ; Correlation analysis ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - physiopathology ; Diagnosis ; Drugs ; Female ; Functional Neuroimaging ; Humans ; Infrared spectroscopy ; Longitudinal Studies ; Male ; Medical imaging ; Mental depression ; Middle Aged ; Near infrared radiation ; Near infrared spectroscopy ; Neuroimaging ; Neurology ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Oxyhemoglobins - metabolism ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiopathology ; Psychiatric Status Rating Scales ; Spectroscopy, Near-Infrared ; Temporal Lobe - drug effects ; Temporal Lobe - physiopathology</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0120828-e0120828</ispartof><rights>2015 Tomioka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Tomioka et al 2015 Tomioka et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-710994e2a053512b7612e53eb8011aa3daf7fa9ccdfacf0086bfbed140890d583</citedby><cites>FETCH-LOGICAL-c592t-710994e2a053512b7612e53eb8011aa3daf7fa9ccdfacf0086bfbed140890d583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364958/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364958/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25786240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomioka, Hiroi</creatorcontrib><creatorcontrib>Yamagata, Bun</creatorcontrib><creatorcontrib>Kawasaki, Shingo</creatorcontrib><creatorcontrib>Pu, Shenghong</creatorcontrib><creatorcontrib>Iwanami, Akira</creatorcontrib><creatorcontrib>Hirano, Jinichi</creatorcontrib><creatorcontrib>Nakagome, Kazuyuki</creatorcontrib><creatorcontrib>Mimura, Masaru</creatorcontrib><title>A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent studies have indicated the potential clinical use of near infrared spectroscopy (NIRS) as a tool in assisting the diagnosis of major depressive disorder (MDD); however, it is still unclear whether NIRS signal changes during cognitive task are state- or trait-dependent, and whether NIRS could be a neural predictor of treatment response. Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression.</description><subject>Adult</subject><subject>Aged</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Bioindicators</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bipolar disorder</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cognitive ability</subject><subject>Correlation analysis</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diagnosis</subject><subject>Drugs</subject><subject>Female</subject><subject>Functional Neuroimaging</subject><subject>Humans</subject><subject>Infrared spectroscopy</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Near infrared radiation</subject><subject>Near infrared spectroscopy</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Spectroscopy, Near-Infrared</subject><subject>Temporal Lobe - drug effects</subject><subject>Temporal Lobe - physiopathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUttu1DAUjBCIlsIfIIjECy9ZfEkc-wWpqrhUqsQLPFsnzvHiJWsvtlOpX9WP4Mfw7qZVi3jy0fHMeMaaqnpNyYrynn7YhDl6mFa74HFFKCOSySfVKVWcNYIR_vTBfFK9SGlDSMelEM-rE9b1UrCWnFa_zusp-LXL8-iKWm1nb7IL-9HjHIPbwtr5dZ0K4KZ2vt7i6AzsIY2HP7fXWI-4i5hS2dRgM8YafHbLsox1jgh5iz6_rJ5ZmBK-Ws6z6sfnT98vvjZX375cXpxfNaZTLDc9JUq1yKDY7SgbekEZdhwHSSgF4CPY3oIyZrRgLCFSDHbAkbZEKjJ2kp9Vb4-6uykkvfxT0lSItu2UIn1BXB4RY4CN3sWSMt7oAE4fFiGuNcTszISaDkJKxm2LhS1QQM84cqasEDByhUXr4_LaPJTPMSVohOmR6OMb737qdbjWLRetOth9vwjE8HvGlPXWJYPTBB7DfPDdUap6Tgv03T_Q_6drjygTQ0oR7b0ZSvS-O3csve-OXrpTaG8eBrkn3ZWF_wUWjsXb</recordid><startdate>20150318</startdate><enddate>20150318</enddate><creator>Tomioka, Hiroi</creator><creator>Yamagata, Bun</creator><creator>Kawasaki, Shingo</creator><creator>Pu, Shenghong</creator><creator>Iwanami, Akira</creator><creator>Hirano, Jinichi</creator><creator>Nakagome, Kazuyuki</creator><creator>Mimura, Masaru</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150318</creationdate><title>A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment</title><author>Tomioka, Hiroi ; Yamagata, Bun ; Kawasaki, Shingo ; Pu, Shenghong ; Iwanami, Akira ; Hirano, Jinichi ; Nakagome, Kazuyuki ; Mimura, Masaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-710994e2a053512b7612e53eb8011aa3daf7fa9ccdfacf0086bfbed140890d583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Bioindicators</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bipolar disorder</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Cognitive ability</topic><topic>Correlation analysis</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diagnosis</topic><topic>Drugs</topic><topic>Female</topic><topic>Functional Neuroimaging</topic><topic>Humans</topic><topic>Infrared spectroscopy</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Near infrared radiation</topic><topic>Near infrared spectroscopy</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxyhemoglobins - 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Therefore, we conducted a longitudinal study to explore frontal haemodynamic changes following antidepressant treatment in medication-naïve MDD using 52-channel NIRS. This study included 25 medication-naïve individuals with MDD and 62 healthy controls (HC). We performed NIRS scans before and after antidepressant treatment and measured changes of [oxy-Hb] activation during a verbal fluency task (VFT) following treatment. Individuals with MDD showed significantly decreased [oxy-Hb] values during a VFT compared with HC in the bilateral frontal and temporal cortices at baseline. There were no [oxy-Hb] changes between pre- and post-antidepressant treatment time points in the MDD cohort despite significant improvement in depressive symptoms. There was a significant association between mean [oxy-Hb] values during a VFT at baseline and improvement in depressive symptoms following treatment in the bilateral inferior frontal and middle temporal gyri in MDD. These findings suggest that hypofrontality response to a VFT may represent a potential trait marker for depression rather than a state marker. Moreover, the correlation analysis indicates that the NIRS signals before the initiation of treatment may be a biological marker to predict patient's clinical response to antidepressant treatment. The present study provides further evidence to support a potential application of NIRS for the diagnosis and treatment of depression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25786240</pmid><doi>10.1371/journal.pone.0120828</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antidepressants Antidepressive Agents - therapeutic use Bioindicators Biomarkers Biomarkers - blood Bipolar disorder Brain Mapping Case-Control Studies Cognitive ability Correlation analysis Depressive Disorder, Major - blood Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - physiopathology Diagnosis Drugs Female Functional Neuroimaging Humans Infrared spectroscopy Longitudinal Studies Male Medical imaging Mental depression Middle Aged Near infrared radiation Near infrared spectroscopy Neuroimaging Neurology Neuropsychological Tests NMR Nuclear magnetic resonance Oxyhemoglobins - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Psychiatric Status Rating Scales Spectroscopy, Near-Infrared Temporal Lobe - drug effects Temporal Lobe - physiopathology |
| title | A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment |
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