Quantitative structure-property relationship (QSPR) modeling of drug-loaded polymeric micelles via genetic function approximation

Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug ca...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119575
Hauptverfasser:	Wu, Wensheng, Zhang, Canyang, Lin, Wenjing, Chen, Quan, Guo, Xindong, Qian, Yu, Zhang, Lijuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Approximation Cancer Chemical engineering Chemistry Computer simulation Cyclin-dependent kinases Drug carriers Drug Carriers - chemistry Drug delivery Drug delivery systems Drugs Genetic algorithms Mathematical analysis Methods Micelles Optimization Polymerization Polymers Quantitative analysis Quantitative Structure-Activity Relationship Self-assembly Studies Surfactants Work capacity
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