Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue. The aim of this study was to investigate GH after OG in relat...
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| description | Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue.
The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity.
We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed.
The AUC of GH (μg/L•min) was lower in obese (249.8±41.8) than in healthy women (490.4±74.6), P=0.001. The AUC of total ghrelin (pg/mL•min) was lower in obese (240995.5±11094.2) than in healthy women (340797.5±37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH. |
| doi_str_mv | 10.1371/journal.pone.0121087 |
| format | Article |
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The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity.
We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed.
The AUC of GH (μg/L•min) was lower in obese (249.8±41.8) than in healthy women (490.4±74.6), P=0.001. The AUC of total ghrelin (pg/mL•min) was lower in obese (240995.5±11094.2) than in healthy women (340797.5±37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0121087</identifier><identifier>PMID: 25782001</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Adiposity ; Adult ; Analysis ; Female ; Ghrelin ; Ghrelin - blood ; Glucose ; Glucose - administration & dosage ; Growth hormone ; Growth hormones ; Hormone release ; Human Growth Hormone - blood ; Humans ; Insulin ; Insulin Resistance ; Insulin secretion ; Multivariate analysis ; Nutritional status ; Obesity ; Obesity - blood ; Regression analysis ; Rodents ; Secretion ; Somatotropin ; Substrates ; Women's health</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0121087-e0121087</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Pena-Bello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Pena-Bello et al 2015 Pena-Bello et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-1da3ae8b11b3c8f1ab1e248a7f264640ff11270078a8e56d78773bdc772a1faa3</citedby><cites>FETCH-LOGICAL-c758t-1da3ae8b11b3c8f1ab1e248a7f264640ff11270078a8e56d78773bdc772a1faa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363632/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363632/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25782001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Seoane, Luísa M</contributor><creatorcontrib>Pena-Bello, Lara</creatorcontrib><creatorcontrib>Pertega-Diaz, Sonia</creatorcontrib><creatorcontrib>Outeiriño-Blanco, Elena</creatorcontrib><creatorcontrib>Garcia-Buela, Jesus</creatorcontrib><creatorcontrib>Tovar, Sulay</creatorcontrib><creatorcontrib>Sangiao-Alvarellos, Susana</creatorcontrib><creatorcontrib>Dieguez, Carlos</creatorcontrib><creatorcontrib>Cordido, Fernando</creatorcontrib><title>Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue.
The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity.
We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed.
The AUC of GH (μg/L•min) was lower in obese (249.8±41.8) than in healthy women (490.4±74.6), P=0.001. The AUC of total ghrelin (pg/mL•min) was lower in obese (240995.5±11094.2) than in healthy women (340797.5±37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH.</description><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Analysis</subject><subject>Female</subject><subject>Ghrelin</subject><subject>Ghrelin - blood</subject><subject>Glucose</subject><subject>Glucose - administration & dosage</subject><subject>Growth hormone</subject><subject>Growth hormones</subject><subject>Hormone release</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Insulin secretion</subject><subject>Multivariate analysis</subject><subject>Nutritional status</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Regression analysis</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Somatotropin</subject><subject>Substrates</subject><subject>Women's health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk29r1TAUxosobk6_gWhBEAXvNUl7m15fCGNMvTAY-O9tOE2TNiNNrkm7uY_it_V0txu3sheSQtunv-ecnNOcJHlOyZJmnL6_8ENwYJdb79SSUEZJyR8kh3SdsUXBSPZw7_kgeRLjBSGrrCyKx8kBW_GSEUIPkz-nWivZp16nPoBNGztIH1UKdWeciX2A3niX4hVU5QdXp03wV32btj50mBllqwANxqUOJQwBCPlKoXblO-U-pH2LmLdqTAK12fpo-ut36IiDRVtUDgVzieKNt2kxpnFPk0cabFTPpvtR8uPT6feTL4uz88-bk-OzheSrsl_QGjJQZUVplclSU6ioYnkJXLMiL3KiNaWME8JLKNWqqHnJeVbVknMGVANkR8nLXdyt9VFMXY2CFkXOWEkKhsRmR9QeLsQ2mA7CtfBgxI3gQyMg9EZaJfI1MErXFfYU8nVOq1rLXCqu8I3pYsz2cco2VJ2qpXLYYjsLOv_iTCsafynyrMA1bubNFCD4X4OKvehMlMpacMoPu31zLJKO6Kt_0Purm6gGsADjtMe8cgwqjnO2ygpOWI7U8h4KV606I_EgaIP6zPB2ZkCmV7_7BoYYxebb1_9nz3_O2dd7bKvA9m30dhiPaZyD-Q6UwccYlL5rMiVinKDbbohxgsQ0QWh7sf-D7ky3I5P9BddAGUM</recordid><startdate>20150317</startdate><enddate>20150317</enddate><creator>Pena-Bello, Lara</creator><creator>Pertega-Diaz, Sonia</creator><creator>Outeiriño-Blanco, Elena</creator><creator>Garcia-Buela, Jesus</creator><creator>Tovar, Sulay</creator><creator>Sangiao-Alvarellos, Susana</creator><creator>Dieguez, Carlos</creator><creator>Cordido, Fernando</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150317</creationdate><title>Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin</title><author>Pena-Bello, Lara ; Pertega-Diaz, Sonia ; Outeiriño-Blanco, Elena ; Garcia-Buela, Jesus ; Tovar, Sulay ; Sangiao-Alvarellos, Susana ; Dieguez, Carlos ; Cordido, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-1da3ae8b11b3c8f1ab1e248a7f264640ff11270078a8e56d78773bdc772a1faa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipose tissue</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Analysis</topic><topic>Female</topic><topic>Ghrelin</topic><topic>Ghrelin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pena-Bello, Lara</au><au>Pertega-Diaz, Sonia</au><au>Outeiriño-Blanco, Elena</au><au>Garcia-Buela, Jesus</au><au>Tovar, Sulay</au><au>Sangiao-Alvarellos, Susana</au><au>Dieguez, Carlos</au><au>Cordido, Fernando</au><au>Seoane, Luísa M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-17</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0121087</spage><epage>e0121087</epage><pages>e0121087-e0121087</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue.
The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity.
We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed.
The AUC of GH (μg/L•min) was lower in obese (249.8±41.8) than in healthy women (490.4±74.6), P=0.001. The AUC of total ghrelin (pg/mL•min) was lower in obese (240995.5±11094.2) than in healthy women (340797.5±37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25782001</pmid><doi>10.1371/journal.pone.0121087</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adipose tissue Adiposity Adult Analysis Female Ghrelin Ghrelin - blood Glucose Glucose - administration & dosage Growth hormone Growth hormones Hormone release Human Growth Hormone - blood Humans Insulin Insulin Resistance Insulin secretion Multivariate analysis Nutritional status Obesity Obesity - blood Regression analysis Rodents Secretion Somatotropin Substrates Women's health |
| title | Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin |
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