Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis
Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery. The present study was performed to...
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| creator | Kim, Jae Heon Shim, Sung Ryul Doo, Seung Whan Yang, Won Jae Yoo, Byung Wook Kim, Joyce Mary Ko, Young Myoung Song, Eun Seop Lim, Ik Sung Lee, Hong Jun Song, Yun Seob |
| description | Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.
The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.
We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.
A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p |
| doi_str_mv | 10.1371/journal.pone.0113491 |
| format | Article |
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The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.
We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.
A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82%), residual urine (-024, p = 0.004, I2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I2 = 0%).
After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0113491</identifier><identifier>PMID: 25781610</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Bladder ; Brain research ; Collaboration ; Contraction ; Data processing ; Humans ; Injuries ; Injury analysis ; Mathematical models ; Medicine ; Mesenchymal stem cells ; Meta-analysis ; Nervous system ; Neurosciences ; Pressure ; Quality of life ; Recovery ; Recovery (Medical) ; Recovery of Function ; Spinal cord injuries ; Spinal Cord Injuries - physiopathology ; Spinal Cord Injuries - therapy ; Stem cell transplantation ; Stem Cell Transplantation - methods ; Stem cells ; Studies ; Subgroups ; Systematic review ; Therapy ; Transplants & implants ; Urinary bladder ; Urinary Bladder - physiopathology ; Urine ; Urogenital system ; Urology</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0113491-e0113491</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kim et al 2015 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3743e45baecd16480d3b0d482b712be5f6728f6dbbd80bec4fe2f1a25481df263</citedby><cites>FETCH-LOGICAL-c692t-3743e45baecd16480d3b0d482b712be5f6728f6dbbd80bec4fe2f1a25481df263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25781610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Banik, Naren L.</contributor><creatorcontrib>Kim, Jae Heon</creatorcontrib><creatorcontrib>Shim, Sung Ryul</creatorcontrib><creatorcontrib>Doo, Seung Whan</creatorcontrib><creatorcontrib>Yang, Won Jae</creatorcontrib><creatorcontrib>Yoo, Byung Wook</creatorcontrib><creatorcontrib>Kim, Joyce Mary</creatorcontrib><creatorcontrib>Ko, Young Myoung</creatorcontrib><creatorcontrib>Song, Eun Seop</creatorcontrib><creatorcontrib>Lim, Ik Sung</creatorcontrib><creatorcontrib>Lee, Hong Jun</creatorcontrib><creatorcontrib>Song, Yun Seob</creatorcontrib><title>Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.
The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.
We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.
A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82%), residual urine (-024, p = 0.004, I2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I2 = 0%).
After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery.</description><subject>Analysis</subject><subject>Animals</subject><subject>Bladder</subject><subject>Brain research</subject><subject>Collaboration</subject><subject>Contraction</subject><subject>Data processing</subject><subject>Humans</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Mathematical models</subject><subject>Medicine</subject><subject>Mesenchymal stem cells</subject><subject>Meta-analysis</subject><subject>Nervous system</subject><subject>Neurosciences</subject><subject>Pressure</subject><subject>Quality of life</subject><subject>Recovery</subject><subject>Recovery (Medical)</subject><subject>Recovery of Function</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - therapy</subject><subject>Stem cell transplantation</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Systematic review</subject><subject>Therapy</subject><subject>Transplants & implants</subject><subject>Urinary bladder</subject><subject>Urinary Bladder - physiopathology</subject><subject>Urine</subject><subject>Urogenital system</subject><subject>Urology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQLgujDjM2laeuDsC5eBhYWvL2GXE5mMrTNbNKO9kv4mU2d7jKVfZA-9HDyO_9zSU6SPEXZEpECvdm63reiXu5cC8sMIUIrdC85RRXBC4Yzcv_IPkkehbDNspyUjD1MTnBelIih7DT5_b4WWoNPPSi3Bz-kckhDB02qoK5TKQLog9ltwIvdkNp2NFM5xekhmL5VnXVtPNK9ivwosbOxuFQ5r6N72_vhbRqGUVh0VsVsews_U9HqtIFOLESEh2DD4-SBEXWAJ9P_LPn-8cO3i8-Ly6tPq4vzy4ViFe4WpKAEaC4FKI0YLTNNZKZpiWWBsITcsAKXhmkpdZlJUNQANkjgnJZIG8zIWfL8oLurXeDTKANHjFGMC1zhSKwOhHZiy3feNsIP3AnL_zqcX3PhYys18KoSBiGNQIKmtGQS5ziXBldaCloIiFrvpmy9bEAraDsv6pno_KS1G752e04JI2UxFvNqEvDuuofQ8caG8VZEC64_1F0UjJEsoi_-Qe_ubqLWIjZgW-NiXjWK8nOKc8KKnNBILe-g4qehsSq-O2OjfxbwehYQmQ5-dWvRh8BXX7_8P3v1Y86-PGI3IOpuE1zdj68uzEF6AJV3IXgwt0NGGR_X5mYafFwbPq1NDHt2fEG3QTd7Qv4ABmUVTw</recordid><startdate>20150317</startdate><enddate>20150317</enddate><creator>Kim, Jae Heon</creator><creator>Shim, Sung Ryul</creator><creator>Doo, Seung Whan</creator><creator>Yang, Won Jae</creator><creator>Yoo, Byung Wook</creator><creator>Kim, Joyce Mary</creator><creator>Ko, Young Myoung</creator><creator>Song, Eun Seop</creator><creator>Lim, Ik Sung</creator><creator>Lee, Hong Jun</creator><creator>Song, Yun Seob</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150317</creationdate><title>Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis</title><author>Kim, Jae Heon ; Shim, Sung Ryul ; Doo, Seung Whan ; Yang, Won Jae ; Yoo, Byung Wook ; Kim, Joyce Mary ; Ko, Young Myoung ; Song, Eun Seop ; Lim, Ik Sung ; Lee, Hong Jun ; Song, Yun Seob</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3743e45baecd16480d3b0d482b712be5f6728f6dbbd80bec4fe2f1a25481df263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Bladder</topic><topic>Brain research</topic><topic>Collaboration</topic><topic>Contraction</topic><topic>Data processing</topic><topic>Humans</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Mathematical models</topic><topic>Medicine</topic><topic>Mesenchymal stem cells</topic><topic>Meta-analysis</topic><topic>Nervous system</topic><topic>Neurosciences</topic><topic>Pressure</topic><topic>Quality of life</topic><topic>Recovery</topic><topic>Recovery (Medical)</topic><topic>Recovery of Function</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal Cord Injuries - therapy</topic><topic>Stem cell transplantation</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Systematic review</topic><topic>Therapy</topic><topic>Transplants & implants</topic><topic>Urinary bladder</topic><topic>Urinary Bladder - physiopathology</topic><topic>Urine</topic><topic>Urogenital system</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jae Heon</creatorcontrib><creatorcontrib>Shim, Sung Ryul</creatorcontrib><creatorcontrib>Doo, Seung Whan</creatorcontrib><creatorcontrib>Yang, Won Jae</creatorcontrib><creatorcontrib>Yoo, Byung Wook</creatorcontrib><creatorcontrib>Kim, Joyce Mary</creatorcontrib><creatorcontrib>Ko, Young Myoung</creatorcontrib><creatorcontrib>Song, Eun Seop</creatorcontrib><creatorcontrib>Lim, Ik Sung</creatorcontrib><creatorcontrib>Lee, Hong Jun</creatorcontrib><creatorcontrib>Song, Yun Seob</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jae Heon</au><au>Shim, Sung Ryul</au><au>Doo, Seung Whan</au><au>Yang, Won Jae</au><au>Yoo, Byung Wook</au><au>Kim, Joyce Mary</au><au>Ko, Young Myoung</au><au>Song, Eun Seop</au><au>Lim, Ik Sung</au><au>Lee, Hong Jun</au><au>Song, Yun Seob</au><au>Banik, Naren L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-17</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0113491</spage><epage>e0113491</epage><pages>e0113491-e0113491</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery.
The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI.
We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 - December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method.
A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p <0.00001, I2 = 77%), NVC (-3.58, p <0.00001, I2 = 82%), residual urine (-024, p = 0.004, I2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I2 = 0%).
After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25781610</pmid><doi>10.1371/journal.pone.0113491</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0113491-e0113491 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1664227292 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animals Bladder Brain research Collaboration Contraction Data processing Humans Injuries Injury analysis Mathematical models Medicine Mesenchymal stem cells Meta-analysis Nervous system Neurosciences Pressure Quality of life Recovery Recovery (Medical) Recovery of Function Spinal cord injuries Spinal Cord Injuries - physiopathology Spinal Cord Injuries - therapy Stem cell transplantation Stem Cell Transplantation - methods Stem cells Studies Subgroups Systematic review Therapy Transplants & implants Urinary bladder Urinary Bladder - physiopathology Urine Urogenital system Urology |
| title | Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A52%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bladder%20recovery%20by%20stem%20cell%20based%20cell%20therapy%20in%20the%20bladder%20dysfunction%20induced%20by%20spinal%20cord%20injury:%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Kim,%20Jae%20Heon&rft.date=2015-03-17&rft.volume=10&rft.issue=3&rft.spage=e0113491&rft.epage=e0113491&rft.pages=e0113491-e0113491&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0113491&rft_dat=%3Cgale_plos_%3EA425367534%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1664227292&rft_id=info:pmid/25781610&rft_galeid=A425367534&rft_doaj_id=oai_doaj_org_article_99af11d1ebed4486b2525bf29dba47ae&rfr_iscdi=true |