A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel m...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0116006-e0116006
Hauptverfasser:	Assent, Delphine, Bourgot, Isabelle, Hennuy, Benoît, Geurts, Pierre, Noël, Agnès, Foidart, Jean-Michel, Maquoi, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biological activity Breast cancer Breast carcinoma Breast Neoplasms - pathology Cancer Cancer cells Cell adhesion & migration Cell Cycle - drug effects Cell Line, Tumor Cell proliferation Collagen Collagen (type I) Collagen Type I - chemistry Collagen Type I - pharmacology Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - metabolism Deactivation Developmental biology Discoidin Domain Receptors Fibers Gels Gene expression Gene Expression Regulation, Neoplastic - drug effects Human health sciences Humans Inactivation Kinases Laboratories Matrix metalloproteinase Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Membrane Proteins - metabolism Metalloproteinase Metastases Metastasis Molecular modelling Morphogenesis Oncologie Oncology Pharmacology Plastic plates Plastics Protein-tyrosine kinase receptors Proteinase Receptor Protein-Tyrosine Kinases - metabolism Receptors, Mitogen - metabolism Ribonucleic acid RNA RNA processing RNA Processing, Post-Transcriptional - drug effects Sciences de la santé humaine Signaling Stroma Three dimensional models Transcription Transcriptome - drug effects Tumor Microenvironment - drug effects Tumors Tyrosine
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