Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats

Besides regulating calcium homeostasis, the effects of vitamin D on vascular tone and metabolic disturbances remain scarce in the literature despite an increase intake with high-fructose corn syrup worldwide. We investigated the effects of calcitriol, an active form of vitamin D, on vascular relaxat...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119843
Hauptverfasser:	Chou, Chu-Lin, Pang, Cheng-Yoong, Lee, Tony J F, Fang, Te-Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adiposity - drug effects Angiotensin Angiotensin II Angiotensin II - metabolism Angiotensins Animals Aorta Blood Blood pressure Blood Pressure - drug effects Body weight Body Weight - drug effects Calcitriol Calcitriol - administration & dosage Calcitriol - pharmacology Calcium Calcium homeostasis Calcium phosphates Cellulose Cholesterol Corn Creatinine Diabetes Diet Dosage Dose-Response Relationship, Drug Drug dosages Endothelium Feeding Fructose Fructose - adverse effects Glucose Glucose intolerance Glucose Intolerance - chemically induced Glucose Intolerance - drug therapy Glucose Intolerance - pathology Glucose tolerance Glucose Tolerance Test Homeostasis Hypertension Hypertension - chemically induced Hypertension - drug therapy Hypertension - pathology Internal medicine Intolerance Laboratory animals Male Medicine Metabolic disorders Nutrient deficiency Obesity Obesity, Abdominal - chemically induced Obesity, Abdominal - drug therapy Obesity, Abdominal - pathology Peritoneum Phosphates Rats Rats, Inbred WKY Rodents Studies Syrup Syrups Triglycerides Vasodilation - drug effects Vitamin D Vitamins - administration & dosage Vitamins - pharmacology Weight reduction
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