High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice

High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity and obesity related metabolic complications. In this study, we determined HFD induced development of metabolic disorders on outbred female CD-1 mice in a time dependent manner. Compared to mice on regular cho...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119784-e0119784
Hauptverfasser:	Gao, Mingming, Ma, Yongjie, Liu, Dexi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - physiology Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - pathology Adipose Tissue, White - pathology Adiposity - physiology Animals Body fat Body weight Body weight gain CD36 antigen Chemokine CCL2 - metabolism Chemokines Comparative analysis Complications Cytokines Deposition Diet Diet, High-Fat - adverse effects Disorders Fatty liver Fatty Liver - blood Fatty Liver - pathology Gene expression Glucose Glucose Intolerance - physiopathology Glucose tolerance High fat diet Human populations Hyperinsulinemia Hyperinsulinism - blood Hyperinsulinism - pathology Hypertrophy Inbreeding Inflammation Inflammation - blood Inflammation - pathology Insulin Insulin resistance Insulin Resistance - physiology Intolerance Liver Metabolic disorders Mice Monocyte chemoattractant protein 1 Obesity Obesity - blood Obesity - pathology Pancreas Peroxisome proliferator-activated receptors Pharmaceuticals Pharmacy Rodents Steatosis Triglycerides Triglycerides - blood Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Weight Gain - physiology
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