Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda
Understanding the current epidemiology of malaria and the relationship between intervention coverage, transmission intensity, and burden of disease is important to guide control activities. We aimed to determine the prevalence of anemia, parasitemia, and serological responses to P. falciparum antige...
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| Veröffentlicht in: | PloS one 2015-03, Vol.10 (3), p.e0118901-e0118901 |
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| creator | Yeka, Adoke Nankabirwa, Joaniter Mpimbaza, Arthur Kigozi, Ruth Arinaitwe, Emmanuel Drakeley, Chris Greenhouse, Bryan Kamya, Moses R Dorsey, Grant Staedke, Sarah G |
| description | Understanding the current epidemiology of malaria and the relationship between intervention coverage, transmission intensity, and burden of disease is important to guide control activities. We aimed to determine the prevalence of anemia, parasitemia, and serological responses to P. falciparum antigens, and factors associated with these indicators, in three different epidemiological settings in Uganda.
In 2012, cross-sectional surveys were conducted in 200 randomly selected households from each of three sites: Walukuba, Jinja district (peri-urban); Kihihi, Kanungu district (rural); and Nagongera, Tororo district (rural) with corresponding estimates of annual entomologic inoculation rates (aEIR) of 3.8, 26.6, and 125.0, respectively. Of 2737 participants, laboratory testing was done in 2227 (81.4%), including measurement of hemoglobin, parasitemia using microscopy, and serological responses to P. falciparum apical membrane antigen 1 (AMA-1) and merozoite surface protein 1, 19 kilodalton fragment (MSP-119). Analysis of laboratory results was restricted to 1949 (87.5%) participants aged ≤ 40 years. Prevalence of anemia (hemoglobin < 11.0 g/dL) was significantly higher in Walukuba (18.9%) and Nagongera (17.4%) than in Kihihi (13.1%), and was strongly associated with decreasing age for those ≤ 5 years at all sites. Parasite prevalence was significantly higher in Nagongera (48.3%) than in Walukuba (12.2%) and Kihihi (12.8%), and significantly increased with age to 11 years, and then significantly decreased at all sites. Seropositivity to AMA-1 was 53.3% in Walukuba, 63.0% in Kihihi, and 83.7% in Nagongera and was associated with increasing age at all sites. AMA-1 seroconversion rates strongly correlated with transmission intensity, while serological responses to MSP-119 did not.
Anemia was predominant in young children and parasitemia peaked by 11 years across 3 sites with varied transmission intensity. Serological responses to AMA-1 appeared to best reflect transmission intensity, and may be a more accurate indicator for malaria surveillance than anemia or parasitemia. |
| doi_str_mv | 10.1371/journal.pone.0118901 |
| format | Article |
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In 2012, cross-sectional surveys were conducted in 200 randomly selected households from each of three sites: Walukuba, Jinja district (peri-urban); Kihihi, Kanungu district (rural); and Nagongera, Tororo district (rural) with corresponding estimates of annual entomologic inoculation rates (aEIR) of 3.8, 26.6, and 125.0, respectively. Of 2737 participants, laboratory testing was done in 2227 (81.4%), including measurement of hemoglobin, parasitemia using microscopy, and serological responses to P. falciparum apical membrane antigen 1 (AMA-1) and merozoite surface protein 1, 19 kilodalton fragment (MSP-119). Analysis of laboratory results was restricted to 1949 (87.5%) participants aged ≤ 40 years. Prevalence of anemia (hemoglobin < 11.0 g/dL) was significantly higher in Walukuba (18.9%) and Nagongera (17.4%) than in Kihihi (13.1%), and was strongly associated with decreasing age for those ≤ 5 years at all sites. Parasite prevalence was significantly higher in Nagongera (48.3%) than in Walukuba (12.2%) and Kihihi (12.8%), and significantly increased with age to 11 years, and then significantly decreased at all sites. Seropositivity to AMA-1 was 53.3% in Walukuba, 63.0% in Kihihi, and 83.7% in Nagongera and was associated with increasing age at all sites. AMA-1 seroconversion rates strongly correlated with transmission intensity, while serological responses to MSP-119 did not.
Anemia was predominant in young children and parasitemia peaked by 11 years across 3 sites with varied transmission intensity. Serological responses to AMA-1 appeared to best reflect transmission intensity, and may be a more accurate indicator for malaria surveillance than anemia or parasitemia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0118901</identifier><identifier>PMID: 25768015</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Analysis ; Anemia ; Anemia - complications ; Antigens ; Antigens, Protozoan - immunology ; Apical membrane antigen 1 ; Children ; Collaboration ; Cross-Sectional Studies ; Disease control ; Epidemiology ; Estimates ; Ethics ; Female ; Health sciences ; Hemoglobin ; Hemoglobins ; Households ; Humans ; Hygiene ; Infectious diseases ; Inoculation ; Insecticides ; Laboratory tests ; Malaria ; Malaria, Falciparum - complications ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Male ; Medicine ; Membrane Proteins - immunology ; Merozoite surface protein 1 ; Microscopy ; Middle Aged ; Morbidity ; Parasitemia ; Parasitemia - complications ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Plasmodium falciparum - physiology ; Prevalence ; Protozoan Proteins - immunology ; Public health ; Seroconversion ; Serologic Tests ; Studies ; Surveys ; Surveys and Questionnaires ; Uganda - epidemiology ; Vector-borne diseases ; Young Adult</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0118901-e0118901</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”) Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-788f24880353d5c957638890ca1f401cd172b1c82252a82b3298104bd69ba7ed3</citedby><cites>FETCH-LOGICAL-c692t-788f24880353d5c957638890ca1f401cd172b1c82252a82b3298104bd69ba7ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358889/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358889/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25768015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ng, Lisa F.P.</contributor><creatorcontrib>Yeka, Adoke</creatorcontrib><creatorcontrib>Nankabirwa, Joaniter</creatorcontrib><creatorcontrib>Mpimbaza, Arthur</creatorcontrib><creatorcontrib>Kigozi, Ruth</creatorcontrib><creatorcontrib>Arinaitwe, Emmanuel</creatorcontrib><creatorcontrib>Drakeley, Chris</creatorcontrib><creatorcontrib>Greenhouse, Bryan</creatorcontrib><creatorcontrib>Kamya, Moses R</creatorcontrib><creatorcontrib>Dorsey, Grant</creatorcontrib><creatorcontrib>Staedke, Sarah G</creatorcontrib><title>Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Understanding the current epidemiology of malaria and the relationship between intervention coverage, transmission intensity, and burden of disease is important to guide control activities. We aimed to determine the prevalence of anemia, parasitemia, and serological responses to P. falciparum antigens, and factors associated with these indicators, in three different epidemiological settings in Uganda.
In 2012, cross-sectional surveys were conducted in 200 randomly selected households from each of three sites: Walukuba, Jinja district (peri-urban); Kihihi, Kanungu district (rural); and Nagongera, Tororo district (rural) with corresponding estimates of annual entomologic inoculation rates (aEIR) of 3.8, 26.6, and 125.0, respectively. Of 2737 participants, laboratory testing was done in 2227 (81.4%), including measurement of hemoglobin, parasitemia using microscopy, and serological responses to P. falciparum apical membrane antigen 1 (AMA-1) and merozoite surface protein 1, 19 kilodalton fragment (MSP-119). Analysis of laboratory results was restricted to 1949 (87.5%) participants aged ≤ 40 years. Prevalence of anemia (hemoglobin < 11.0 g/dL) was significantly higher in Walukuba (18.9%) and Nagongera (17.4%) than in Kihihi (13.1%), and was strongly associated with decreasing age for those ≤ 5 years at all sites. Parasite prevalence was significantly higher in Nagongera (48.3%) than in Walukuba (12.2%) and Kihihi (12.8%), and significantly increased with age to 11 years, and then significantly decreased at all sites. Seropositivity to AMA-1 was 53.3% in Walukuba, 63.0% in Kihihi, and 83.7% in Nagongera and was associated with increasing age at all sites. AMA-1 seroconversion rates strongly correlated with transmission intensity, while serological responses to MSP-119 did not.
Anemia was predominant in young children and parasitemia peaked by 11 years across 3 sites with varied transmission intensity. Serological responses to AMA-1 appeared to best reflect transmission intensity, and may be a more accurate indicator for malaria surveillance than anemia or parasitemia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Anemia - complications</subject><subject>Antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Apical membrane antigen 1</subject><subject>Children</subject><subject>Collaboration</subject><subject>Cross-Sectional Studies</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Estimates</subject><subject>Ethics</subject><subject>Female</subject><subject>Health sciences</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Households</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infectious diseases</subject><subject>Inoculation</subject><subject>Insecticides</subject><subject>Laboratory tests</subject><subject>Malaria</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Male</subject><subject>Medicine</subject><subject>Membrane Proteins - immunology</subject><subject>Merozoite surface protein 1</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Parasitemia</subject><subject>Parasitemia - complications</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Plasmodium falciparum - physiology</subject><subject>Prevalence</subject><subject>Protozoan Proteins - immunology</subject><subject>Public health</subject><subject>Seroconversion</subject><subject>Serologic Tests</subject><subject>Studies</subject><subject>Surveys</subject><subject>Surveys and Questionnaires</subject><subject>Uganda - epidemiology</subject><subject>Vector-borne diseases</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQLgig4Y25N0xdhWVwdWFhQ19dwmqSdDJ1mNkm9PPrNzcx0h6nsg-ThhOR3_jmXnCx7jtEc0xK_X7nB99DNN643c4SxqBB-kJ3iipIZJ4g-PNqfZE9CWCFUUMH54-yEFCUXCBen2Z9LUNH5kEMITlmIRuc_bVzma-jAW8g34CHYaNYW3uXQb20yOg_Gu861VkGXexNSFMGE3PY55GFjVPTDOndNbjZWJ58DGkyMtm935E2bhOBp9qiBLphnoz3Lbi4_frv4PLu6_rS4OL-aKV6ROCuFaAgTAtGC6kJVKQMqUs4KcMMQVhqXpMZKEFIQEKSmpBIYsVrzqobSaHqWvdzrbjoX5Fi9IDHnlLISEZGIxZ7QDlZy4-0a_G_pwMrdgfOtBB-t6owsdVNwaGpSaM0IZxUTNeNaoxQRMGOS1ofxtaFeG61MHz10E9HpTW-XsnU_JKOFSHklgTejgHe3gwlRrm1QputSD9ywi5sRzFOHE_rqH_T-7EaqhZSA7RuX3lVbUXnOCEGEF9VWa34Plda2iyp9tcam84nD24lDYqL5FVsYQpCLr1_-n73-PmVfH7FLA11cBtcN0aafNgXZHlTeheBNcygyRnI7KXfVkNtJkeOkJLcXxw06ON2NBv0LrpwOwQ</recordid><startdate>20150313</startdate><enddate>20150313</enddate><creator>Yeka, Adoke</creator><creator>Nankabirwa, Joaniter</creator><creator>Mpimbaza, Arthur</creator><creator>Kigozi, Ruth</creator><creator>Arinaitwe, Emmanuel</creator><creator>Drakeley, Chris</creator><creator>Greenhouse, Bryan</creator><creator>Kamya, Moses R</creator><creator>Dorsey, Grant</creator><creator>Staedke, Sarah G</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150313</creationdate><title>Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda</title><author>Yeka, Adoke ; Nankabirwa, Joaniter ; Mpimbaza, Arthur ; Kigozi, Ruth ; Arinaitwe, Emmanuel ; Drakeley, Chris ; Greenhouse, Bryan ; Kamya, Moses R ; Dorsey, Grant ; Staedke, Sarah G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-788f24880353d5c957638890ca1f401cd172b1c82252a82b3298104bd69ba7ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis</topic><topic>Anemia</topic><topic>Anemia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeka, Adoke</au><au>Nankabirwa, Joaniter</au><au>Mpimbaza, Arthur</au><au>Kigozi, Ruth</au><au>Arinaitwe, Emmanuel</au><au>Drakeley, Chris</au><au>Greenhouse, Bryan</au><au>Kamya, Moses R</au><au>Dorsey, Grant</au><au>Staedke, Sarah G</au><au>Ng, Lisa F.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-13</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0118901</spage><epage>e0118901</epage><pages>e0118901-e0118901</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Understanding the current epidemiology of malaria and the relationship between intervention coverage, transmission intensity, and burden of disease is important to guide control activities. We aimed to determine the prevalence of anemia, parasitemia, and serological responses to P. falciparum antigens, and factors associated with these indicators, in three different epidemiological settings in Uganda.
In 2012, cross-sectional surveys were conducted in 200 randomly selected households from each of three sites: Walukuba, Jinja district (peri-urban); Kihihi, Kanungu district (rural); and Nagongera, Tororo district (rural) with corresponding estimates of annual entomologic inoculation rates (aEIR) of 3.8, 26.6, and 125.0, respectively. Of 2737 participants, laboratory testing was done in 2227 (81.4%), including measurement of hemoglobin, parasitemia using microscopy, and serological responses to P. falciparum apical membrane antigen 1 (AMA-1) and merozoite surface protein 1, 19 kilodalton fragment (MSP-119). Analysis of laboratory results was restricted to 1949 (87.5%) participants aged ≤ 40 years. Prevalence of anemia (hemoglobin < 11.0 g/dL) was significantly higher in Walukuba (18.9%) and Nagongera (17.4%) than in Kihihi (13.1%), and was strongly associated with decreasing age for those ≤ 5 years at all sites. Parasite prevalence was significantly higher in Nagongera (48.3%) than in Walukuba (12.2%) and Kihihi (12.8%), and significantly increased with age to 11 years, and then significantly decreased at all sites. Seropositivity to AMA-1 was 53.3% in Walukuba, 63.0% in Kihihi, and 83.7% in Nagongera and was associated with increasing age at all sites. AMA-1 seroconversion rates strongly correlated with transmission intensity, while serological responses to MSP-119 did not.
Anemia was predominant in young children and parasitemia peaked by 11 years across 3 sites with varied transmission intensity. Serological responses to AMA-1 appeared to best reflect transmission intensity, and may be a more accurate indicator for malaria surveillance than anemia or parasitemia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25768015</pmid><doi>10.1371/journal.pone.0118901</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0118901-e0118901 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1663347028 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Analysis Anemia Anemia - complications Antigens Antigens, Protozoan - immunology Apical membrane antigen 1 Children Collaboration Cross-Sectional Studies Disease control Epidemiology Estimates Ethics Female Health sciences Hemoglobin Hemoglobins Households Humans Hygiene Infectious diseases Inoculation Insecticides Laboratory tests Malaria Malaria, Falciparum - complications Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Male Medicine Membrane Proteins - immunology Merozoite surface protein 1 Microscopy Middle Aged Morbidity Parasitemia Parasitemia - complications Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - physiology Prevalence Protozoan Proteins - immunology Public health Seroconversion Serologic Tests Studies Surveys Surveys and Questionnaires Uganda - epidemiology Vector-borne diseases Young Adult |
| title | Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda |
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