Tracking the fate of stem cell implants with fluorine-19 MRI

In this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a Fluorine-19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells. We investigated two common stem cell transplant mouse models: an immune com...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118544-e0118544
Hauptverfasser:	Gaudet, Jeffrey M, Ribot, Emeline J, Chen, Yuhua, Gilbert, Kyle M, Foster, Paula J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animal models Animals Biophysics Bone marrow Cell adhesion & migration Cell culture Cell number Cell Tracking - methods Dendritic cells Disease Models, Animal Fluorescence Fluorescence microscopy Fluorides Fluorine Fluorine Radioisotopes - administration & dosage Humans Immunohistochemistry In vivo methods and tests Ionizing radiation Labeling Laboratories Macrophages Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mesenchyme Mice Mice, Inbred C57BL Microscopy Microscopy, Fluorescence - methods Nanoemulsions Nanoparticles NMR Nuclear magnetic resonance Perfluorocarbons Stem cell transplantation Stem cells Surgical implants Syngeneic grafts Transplantation Transplants & implants Xenografts
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