Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein

Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic back...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118859-e0118859
Hauptverfasser:	Ligthart, Symen, de Vries, Paul S, Uitterlinden, André G, Hofman, Albert, Franco, Oscar H, Chasman, Daniel I, Dehghan, Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological effects C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Causation Cholesterol Consortia Coronary vessels Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Epidemiology Fasting Female Gene expression Gene loci Genetic analysis Genetic diversity Genetic Loci - genetics Genetic Pleiotropy Genetic variance Genetics Genome-Wide Association Study Genomes Genomics Glucose Health risks Hepatocyte nuclear factor 4 Humans Hypertension Inflammation Insulin Interleukin 1 Interleukin 6 Interleukin 6 receptors Lipids Loci Low density lipoprotein Meta-analysis Metabolic Diseases - genetics Metabolism Mortality Pleiotropy Polymorphism, Single Nucleotide Preventive medicine Proteins Studies Triglycerides Type 2 diabetes Womens health Working groups
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