GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons

The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents. Alzheimer disease's patients exhibit high levels of circulating GSK...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118475-e0118475
Hauptverfasser:	Cuesto, Germán, Jordán-Álvarez, Sheila, Enriquez-Barreto, Lilian, Ferrús, Alberto, Morales, Miguel, Acebes, Ángel
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Age AKT protein Alzheimer's disease Alzheimers disease Animals Antagonists Biomedical research Cell culture Cells, Cultured Coma Comparative studies Disease control Drosophila Drosophila melanogaster - enzymology Drosophila Proteins - metabolism Drug therapy Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hippocampus Hippocampus - cytology Hippocampus - enzymology Humans Inhibition Insects Insulin Kinases Laboratories Mammals Medical research Medical treatment Neurobiology Neurodegenerative diseases Neurogenesis Neurons Neurons - enzymology Neurons - physiology Neurosciences Pharmacology Phosphorylation Rats Rodents Signal Transduction Signaling Synapses Synapses - enzymology Synapses - physiology Synapsin Synapsins - metabolism Synaptic density Synaptogenesis Up-Regulation
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